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ChemicalBook >> CAS DataBase List >> LY 2157299

LY 2157299

LY 2157299 price.
  • $22 - $1802
  • Product name: LY 2157299
  • CAS: 700874-72-2
  • MF: C22H19N5O
  • MW: 369.42
  • EINECS:-0
  • MDL Number:MFCD12923319
  • Synonyms:LY 2157299;4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide;6-QuinolinecarboxaMide, 4-[5,6-dihydro-2-(6-Methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-;4-[2-(6-Methyl-2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxaMideorLY2157299;GALUNISERTIB;Galunisertib,LY2157299;4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide;4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide LY 2157299
49 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 5
  • 1unit
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 25
  • 5g
  • 10mM(in 1mL DMSO)
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7574
  • Product description4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
  • Packaging250mg
  • Price$704
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging2mg
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging5mg
  • Price$38
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging10mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging25mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging50mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging100mg
  • Price$123
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging250mg
  • Price$247
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA150887
  • Product description4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+%
  • Packaging1g
  • Price$614
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000155
  • Product descriptionLY-2157299 95.00%
  • Packaging2MG
  • Price$213
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000155
  • Product descriptionLY-2157299 95.00%
  • Packaging5MG
  • Price$504.54
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8348
  • Product descriptionLY2157299
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8348
  • Product descriptionLY2157299
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8348
  • Product descriptionLY2157299
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8348
  • Product descriptionLY2157299
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8348
  • Product descriptionLY2157299
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7574 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 250mg $704 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 2mg $22 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 5mg $38 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 10mg $52 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 25mg $73 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 50mg $95 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 100mg $123 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 250mg $247 2021-12-16 Buy
Ambeed A150887 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide 98+% 1g $614 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000155 LY-2157299 95.00% 2MG $213 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000155 LY-2157299 95.00% 5MG $504.54 2021-12-16 Buy
ApexBio Technology A8348 LY2157299 1unit $28 2021-12-16 Buy
ApexBio Technology A8348 LY2157299 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A8348 LY2157299 5mg $75 2021-12-16 Buy
ApexBio Technology A8348 LY2157299 10mg $110 2021-12-16 Buy
ApexBio Technology A8348 LY2157299 50mg $350 2021-12-16 Buy

Properties

Melting point :241-242°C
Boiling point :619.0±55.0 °C(Predicted)
Density :1.40
Flash point :328.162℃
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
pka :15.27±0.30(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference :700874-72-2

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-β signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the migration and tumor growth of hepatocellular carcinoma cell lines by disrupting Smad-2 phosphorylation.

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