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ChemicalBook >> CAS DataBase List >> K-252A

K-252A

K-252A price.
  • $57 - $3800
  • Product name: K-252A
  • CAS: 99533-80-9
  • MF: C27H21N3O5
  • MW: 467.47
  • EINECS:640-127-4
  • MDL Number:MFCD09878276
  • Synonyms:(9-alpha,10-beta,12-alpha)-este ;[9S,(+)]-2,3,9,10,11,12-Hexahydro-10α-hydroxy-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-;9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-;(9α,10β,12α)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-Methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid Methyl ester;K 252a(SF 2370);2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0-carboxylicacimethyl ;9,1-epoxy-1h-diindolo(1,2,3-fg:3’,2’,1’-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1
15 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • Alfa Aesar
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • TRC
Package
  • 100UG-F
  • 100μg
  • 0.5mg
  • 1mg
  • 5mg
  • 50mg
  • 200μL
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0019-C100
  • Product descriptionK-252a ≥98%(HPLC)
  • Packaging100μg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61687
  • Product descriptionProtein Kinase Inhibitor
  • Packaging1mg
  • Price$297
  • Updated2023-06-20
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6828
  • Product descriptionK252a
  • Packaging1mg
  • Price$520
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6828
  • Product descriptionK252a
  • Packaging5mg
  • Price$1559
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11338
  • Product descriptionK252a ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11338
  • Product descriptionK252a
  • Packaging5mg
  • Price$208
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014825
  • Product descriptionK-252a 99.45%
  • Packaging1mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014825
  • Product descriptionK-252a 99.45%
  • Packaging5mg
  • Price$990
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number05288
  • Product descriptionK-252a fromNocardiopsissp.
  • Packaging100μg
  • Price$160
  • Updated2023-01-07
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number05288
  • Product descriptionK-252a from Nocardiopsis sp.
  • Packaging100UG-F
  • Price$171
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberK2015
  • Product descriptionK-252a ReadyMadeSolution,fromNonomuraealongicatena,>98%
  • Packaging200μL
  • Price$223
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberK1639
  • Product descriptionK-252a fromNonomuraealongicatena,≥98%(HPLC)
  • Packaging100μg
  • Price$225
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number82497
  • Product descriptionK-252a from Nocardiopsis sp., ≥96.0% (HPLC)
  • Packaging1mg
  • Price$3800
  • Updated2023-01-07
  • Buy
  • ManufacturerTRC
  • Product numberK000500
  • Product descriptionK252a
  • Packaging0.5mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberK000500
  • Product descriptionK252a
  • Packaging50mg
  • Price$1390
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0019-C100 K-252a ≥98%(HPLC) 100μg $60 2021-12-16 Buy
Alfa Aesar J61687 Protein Kinase Inhibitor 1mg $297 2023-06-20 Buy
ApexBio Technology B6828 K252a 1mg $520 2021-12-16 Buy
ApexBio Technology B6828 K252a 5mg $1559 2021-12-16 Buy
Cayman Chemical 11338 K252a ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 11338 K252a 5mg $208 2024-03-01 Buy
ChemScene CS-0014825 K-252a 99.45% 1mg $330 2021-12-16 Buy
ChemScene CS-0014825 K-252a 99.45% 5mg $990 2021-12-16 Buy
Sigma-Aldrich 05288 K-252a fromNocardiopsissp. 100μg $160 2023-01-07 Buy
Sigma-Aldrich 05288 K-252a from Nocardiopsis sp. 100UG-F $171 2024-03-01 Buy
Sigma-Aldrich K2015 K-252a ReadyMadeSolution,fromNonomuraealongicatena,>98% 200μL $223 2024-03-01 Buy
Sigma-Aldrich K1639 K-252a fromNonomuraealongicatena,≥98%(HPLC) 100μg $225 2024-03-01 Buy
Sigma-Aldrich 82497 K-252a from Nocardiopsis sp., ≥96.0% (HPLC) 1mg $3800 2023-01-07 Buy
TRC K000500 K252a 0.5mg $95 2021-12-16 Buy
TRC K000500 K252a 50mg $1390 2021-12-16 Buy

Properties

Melting point :262-273℃ (decomposition) (methanol )
Boiling point :685.3±55.0 °C(Predicted)
Density :1.68
Flash point :87℃
storage temp. :-20°C
solubility :DMF: 1 mg/mL
pka :11.95±0.40(Predicted)
form :Lyophilized solid.
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.

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