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ChemicalBook >> CAS DataBase List >> GSK4027

GSK4027

GSK4027 price.
  • $44 - $3950
  • Product name: GSK4027
  • CAS: 2079896-25-4
  • MF: C17H21BrN4O
  • MW: 377.28
  • EINECS:
  • MDL Number:MFCD31692324
  • Synonyms:GSK4027;GSK4207;3(2H)-Pyridazinone, 4-bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-
10 prices
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Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number3339EJ
  • Product description4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one
  • Packaging5mg
  • Price$253
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166671
  • Product descriptionGSK 4027
  • Packaging10mg
  • Price$285
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23421
  • Product descriptionGSK4027
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23421
  • Product descriptionGSK4027
  • Packaging5mg
  • Price$140
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23421
  • Product descriptionGSK4027
  • Packaging10mg
  • Price$257
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging5mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging10mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging25mg
  • Price$1750
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging50mg
  • Price$2750
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging100mg
  • Price$3950
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3339EJ 4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one 5mg $253 2021-12-16 Buy
Biosynth Carbosynth BG166671 GSK 4027 10mg $285 2021-12-16 Buy
Cayman Chemical 23421 GSK4027 1mg $44 2024-03-01 Buy
Cayman Chemical 23421 GSK4027 5mg $140 2024-03-01 Buy
Cayman Chemical 23421 GSK4027 10mg $257 2024-03-01 Buy
ChemScene CS-0020734 GSK4027 98.01% 5mg $550 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 10mg $850 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 25mg $1750 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 50mg $2750 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 100mg $3950 2021-12-16 Buy

Properties

Boiling point :450.3±55.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:50.0(Max Conc. mg/mL);132.53(Max Conc. mM)
form :A crystalline solid
pka :9.58±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

GSK4027 is a potent and selective chemical probe for the PCAF/GCN5 bromodomain. GSK4027 has PCAF TR-FRET pIC50 = 7.4 ; PCAF BROMOscan pKi = 8.9; GCN5 BROMOscan pKi = 8.9; PCAF NanoBRET pIC50 =7.2; BRD4 BD1 TR-FRET pIC50 < 4.3. GSK4027 shows high potency for the PCAF/GCN5 bromodomain, high solubility, cellular target engagement, and ≥18000-fold selectivity over the BET family, together with ≥70-fold selectivity over the wider bromodomain families. p300/CREB binding protein associated factor (PCAF/KAT2B) and general control nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in retroviral infection, inflammation pathways, and cancer development.