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ChemicalBook >> CAS DataBase List >> Chlortalidone

Chlortalidone

Chlortalidone price.
  • $29 - $598.6
  • Product name: Chlortalidone
  • CAS: 77-36-1
  • MF: C14H11ClN2O4S
  • MW: 338.77
  • EINECS:201-022-5
  • MDL Number:MFCD00036257
  • Synonyms:thalitone;2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1h-isoindol-1-yl)benzenesulfonamide;hygroton;CHLORTHALIDONE;CHLORTALIDONE;1-keto-3-(3’-sulfamyl-4’-chlorophenyl)-3-hydroxyisoindoline ;1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline ;2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-benzenesulfonamid
33 prices
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Brand
  • AHH
  • AK Scientific
  • American Custom Chemicals Corporation
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
Package
  • c1950000
  • 50mg
  • 200mg
  • 250mg
  • Y0002129
  • 5mg
  • 10mg
  • 25mg
  • 100mg
  • 1g
  • 10g
  • 25g
  • 50g
  • 100g
  • 250g
  • ManufacturerAHH
  • Product numberAPI-1560
  • Product descriptionChlorthalidone 98%
  • Packaging1g
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH530
  • Product descriptionChlorthalidone
  • Packaging5mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH530
  • Product descriptionChlorthalidone
  • Packaging25mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH530
  • Product descriptionChlorthalidone
  • Packaging100mg
  • Price$267
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001976
  • Product descriptionCHLORTHALIDONE 95.00%
  • Packaging25MG
  • Price$449.65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001976
  • Product descriptionCHLORTHALIDONE 95.00%
  • Packaging100MG
  • Price$598.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3756
  • Product descriptionChlortalidone
  • Packaging25mg
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3756
  • Product descriptionChlortalidone
  • Packaging100mg
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3756
  • Product descriptionChlortalidone
  • Packaging1g
  • Price$449
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20414
  • Product description2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide
  • Packaging10g
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20414
  • Product description2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide
  • Packaging25g
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20414
  • Product description2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide
  • Packaging50g
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20414
  • Product description2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide
  • Packaging100g
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20414
  • Product description2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide
  • Packaging250g
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16213
  • Product descriptionChlorthalidone ≥98%
  • Packaging5mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16213
  • Product descriptionChlorthalidone ≥98%
  • Packaging10mg
  • Price$73
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1560 Chlorthalidone 98% 1g $400 2021-12-16 Buy
AK Scientific H530 Chlorthalidone 5mg $29 2021-12-16 Buy
AK Scientific H530 Chlorthalidone 25mg $95 2021-12-16 Buy
AK Scientific H530 Chlorthalidone 100mg $267 2021-12-16 Buy
American Custom Chemicals Corporation API0001976 CHLORTHALIDONE 95.00% 25MG $449.65 2021-12-16 Buy
American Custom Chemicals Corporation API0001976 CHLORTHALIDONE 95.00% 100MG $598.6 2021-12-16 Buy
AvaChem 3756 Chlortalidone 25mg $79 2021-12-16 Buy
AvaChem 3756 Chlortalidone 100mg $149 2021-12-16 Buy
AvaChem 3756 Chlortalidone 1g $449 2021-12-16 Buy
Biosynth Carbosynth FC20414 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide 10g $58 2021-12-16 Buy
Biosynth Carbosynth FC20414 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide 25g $110 2021-12-16 Buy
Biosynth Carbosynth FC20414 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide 50g $170 2021-12-16 Buy
Biosynth Carbosynth FC20414 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide 100g $250 2021-12-16 Buy
Biosynth Carbosynth FC20414 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide 250g $400 2021-12-16 Buy
Cayman Chemical 16213 Chlorthalidone ≥98% 5mg $49 2024-03-01 Buy
Cayman Chemical 16213 Chlorthalidone ≥98% 10mg $73 2024-03-01 Buy

Properties

Melting point :265-267°C (dec.)
Density :1.3356 (rough estimate)
refractive index :1.5630 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :pKa 9.4 (Uncertain)
form :powder
color :white to beige
Water Solubility :0.12g/L(25 ºC)
Stability :Hygroscopic
InChIKey :JIVPVXMEBJLZRO-UHFFFAOYSA-N
NIST Chemistry Reference :Chlorthalidone(77-36-1)
EPA Substance Registry System :Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)- (77-36-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Chlorthalidone is a nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC50s = 2.8 nM - 11 μM), which has been attributed to the sustained vasodilator capability of this compound. Chlorthalidone has been used independently or in combination with other antihypertensive agents to lower arterial blood pressure, and also as an adjuvant to address edema caused by cardiac or renal disorders.

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