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ChemicalBook >> CAS DataBase List >> (-)-COTININE

(-)-COTININE

(-)-COTININE price.
  • $27.7 - $2083
  • Product name: (-)-COTININE
  • CAS: 486-56-6
  • MF: C10H12N2O
  • MW: 176.22
  • EINECS:207-634-9
  • MDL Number:MFCD00077696
  • Synonyms:L-COTININE;(-)-COTININE;(S)-(-)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE;[S]-1-METHYL-5-[3-PYRIDYL]-2-PYRROLIDINONE;S(-)-1-METHYL-5-(3-PYRIDYL)-2-PYRROLIDONE;(s)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone ;(s)-2-pyrrolidinon ;1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
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  • ACHEMBLOCK
  • Alfa Aesar
  • Ambeed
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • Matrix Scientific
  • Sigma-Aldrich
  • SynQuest Laboratories
  • TRC
  • Usbiological
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  • 1g
  • 1mL
  • 10mM(in 1mL DMSO)
  • 2g
  • 5G
  • ManufacturerACHEMBLOCK
  • Product numberG-5334
  • Product description(-)-Cotinine 97%
  • Packaging5G
  • Price$2083
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberL11873
  • Product description(-)-Cotinine, 98%
  • Packaging250mg
  • Price$78.4
  • Updated2024-03-01
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  • ManufacturerAlfa Aesar
  • Product numberL11873
  • Product description(-)-Cotinine, 98%
  • Packaging1g
  • Price$186
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA431146
  • Product description(S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one 98+%
  • Packaging50mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA431146
  • Product description(S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one 98+%
  • Packaging100mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA431146
  • Product description(S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one 98+%
  • Packaging250mg
  • Price$114
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7277
  • Product description(-)-Cotinine
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB7277
  • Product description(-)-Cotinine
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20565
  • Product descriptionS-(-)-Cotinine
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20565
  • Product descriptionS-(-)-Cotinine
  • Packaging250mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20565
  • Product descriptionS-(-)-Cotinine
  • Packaging500mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20565
  • Product descriptionS-(-)-Cotinine
  • Packaging1g
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20565
  • Product descriptionS-(-)-Cotinine
  • Packaging2g
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15314
  • Product description(-)-Cotinine ≥98%
  • Packaging50mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15314
  • Product description(-)-Cotinine ≥98%
  • Packaging100mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15314
  • Product description(-)-Cotinine ≥98%
  • Packaging250mg
  • Price$92
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK G-5334 (-)-Cotinine 97% 5G $2083 2021-12-16 Buy
Alfa Aesar L11873 (-)-Cotinine, 98% 250mg $78.4 2024-03-01 Buy
Alfa Aesar L11873 (-)-Cotinine, 98% 1g $186 2024-03-01 Buy
Ambeed A431146 (S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one 98+% 50mg $42 2021-12-16 Buy
Ambeed A431146 (S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one 98+% 100mg $76 2021-12-16 Buy
Ambeed A431146 (S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-one 98+% 250mg $114 2021-12-16 Buy
ApexBio Technology B7277 (-)-Cotinine 50mg $50 2021-12-16 Buy
ApexBio Technology B7277 (-)-Cotinine 10mM(in 1mL DMSO) $50 2021-12-16 Buy
Biosynth Carbosynth FC20565 S-(-)-Cotinine 100mg $50 2021-12-16 Buy
Biosynth Carbosynth FC20565 S-(-)-Cotinine 250mg $100 2021-12-16 Buy
Biosynth Carbosynth FC20565 S-(-)-Cotinine 500mg $160 2021-12-16 Buy
Biosynth Carbosynth FC20565 S-(-)-Cotinine 1g $250 2021-12-16 Buy
Biosynth Carbosynth FC20565 S-(-)-Cotinine 2g $450 2021-12-16 Buy
Cayman Chemical 15314 (-)-Cotinine ≥98% 50mg $57 2024-03-01 Buy
Cayman Chemical 15314 (-)-Cotinine ≥98% 100mg $73 2024-03-01 Buy
Cayman Chemical 15314 (-)-Cotinine ≥98% 250mg $92 2024-03-01 Buy

Properties

Melting point :40-42 °C(lit.)
Boiling point :250 °C150 mm Hg(lit.)
alpha :[α]D20 -18~-22° (c=1, C2H5OH)
Density :1.1102 (rough estimate)
refractive index :1.7110 (estimate)
Flash point :>230 °F
storage temp. :Sealed in dry,2-8°C
solubility :Chloroform (Sparingly), DMSO (Slightly), Methanol (Sparingly)
form :Solid
pka :4.72±0.12(Predicted)
color :Colourless to Very Dark Orange Oil
optical activity :[α]/D -21±2°, c = 1 in ethanol
Water Solubility :Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Merck :14,2553
BRN :83099
Stability :Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold.
EPA Substance Registry System :Cotinine (486-56-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cotinine is a minor alkaloid found in tobacco plants and is a major metabolite of nicotine. It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours) and is often used as a biomarker to detect tobacco use. Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

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