AZ191
- $25 - $2100
- Product name: AZ191
- CAS: 1594092-37-1
- MF: C24H27N7O
- MW: 429.52
- EINECS:
- MDL Number:MFCD28015098
- Synonyms:N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191;[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine;AZ191;AZ-191;AZ 191;CS-1824;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine;2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-;Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK
24 prices
-
Adipogen Life Sciences
-
AK Scientific
-
Ambeed
-
Cayman Chemical
-
Chemenu
-
ChemScene
-
Crysdot
-
DC Chemicals
-
Tocris
-
TRC
- 50
- 1mg
- 10
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
| Manufacturer |
Product number |
Product description |
Packaging |
Price |
Updated |
Buy |
|
Adipogen Life Sciences
| AG-CR1-3657-M001 |
AZ191 ≥98% |
1mg |
$25 |
2021-12-16 |
Buy |
|
Adipogen Life Sciences
| AG-CR1-3657-M005 |
AZ191 ≥98% |
5mg |
$90 |
2021-12-16 |
Buy |
|
Adipogen Life Sciences
| AG-CR1-3657-M025 |
AZ191 ≥98% |
25mg |
$360 |
2021-12-16 |
Buy |
|
AK Scientific
| Y1892 |
AZ191 |
1mg |
$133 |
2021-12-16 |
Buy |
|
AK Scientific
| Y1892 |
AZ191 |
5mg |
$218 |
2021-12-16 |
Buy |
|
Ambeed
| A404720 |
Az191 98+% |
1mg |
$37 |
2021-12-16 |
Buy |
|
Ambeed
| A404720 |
Az191 98+% |
5mg |
$82 |
2021-12-16 |
Buy |
|
Ambeed
| A404720 |
Az191 98+% |
10mg |
$122 |
2021-12-16 |
Buy |
|
Cayman Chemical
| 17693 |
AZ191 ≥98% |
1mg |
$32 |
2024-03-01 |
Buy |
|
Cayman Chemical
| 17693 |
AZ191 ≥98% |
5mg |
$109 |
2024-03-01 |
Buy |
|
Cayman Chemical
| 17693 |
AZ191 ≥98% |
10mg |
$199 |
2024-03-01 |
Buy |
|
Cayman Chemical
| 17693 |
AZ191 ≥98% |
25mg |
$456 |
2024-03-01 |
Buy |
|
Chemenu
| CM295223 |
N-(2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine 95%+ |
100mg |
$458 |
2021-12-16 |
Buy |
|
ChemScene
| CS-4277 |
AZ191 99.98% |
5mg |
$72 |
2021-12-16 |
Buy |
|
ChemScene
| CS-4277 |
AZ191 99.98% |
10mg |
$108 |
2021-12-16 |
Buy |
|
ChemScene
| CS-4277 |
AZ191 99.98% |
50mg |
$300 |
2021-12-16 |
Buy |
Properties
Boiling point :705.3±70.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :7.76±0.42(Predicted)
color :white to yellow to light brown
Safety Information
| Symbol(GHS): |
|
| Signal word: |
Danger |
| Hazard statements: |
| Code |
Hazard statements |
Hazard class |
Category |
Signal word |
Pictogram |
P-Codes |
| H227 |
Combustible liquid |
Flammable liquids |
Category 4 |
Warning |
|
P210, P280, P370+P378, P403+P235,P501 |
| H301 |
Toxic if swalloed |
Acute toxicity,oral |
Category 3 |
Danger |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| Precautionary statements: |
| P210 |
Keep away from heat/sparks/open flames/hot surfaces. — No smoking. |
| P264 |
Wash hands thoroughly after handling. |
| P264 |
Wash skin thouroughly after handling. |
| P270 |
Do not eat, drink or smoke when using this product. |
| P280 |
Wear protective gloves/protective clothing/eye protection/face protection. |
| P370+P378 |
In case of fire: Use … for extinction. |
| P403+P235 |
Store in a well-ventilated place. Keep cool. |
| P405 |
Store locked up. |
| P501 |
Dispose of contents/container to..… |
|
Description
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome. AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. This compound has been used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression.{28993
