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ChemicalBook >> CAS DataBase List >> 7-Dehydrocholesterol

7-Dehydrocholesterol

7-Dehydrocholesterol price.
  • $10 - $3712.5
  • Product name: 7-Dehydrocholesterol
  • CAS: 434-16-2
  • MF: C27H44O
  • MW: 384.64
  • EINECS:207-100-5
  • MDL Number:MFCD00003624
  • Synonyms:(3)-7-Dehydrochlesterol ;(3beta)-Cholesta-5,7-dien-3-ol;(3-beta)-cholesta-7-dien-3-ol ;(3beta)-cholesta-7-dien-3-ol ;3-Hydroxycholesta-5,7-diene ;Cholesta-5,7-dien-3-ol, (3beta)-;Cholesterol, 7-dehydro-;Dehydrocholesterin
34 prices
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Brand
  • Adipogen Life Sciences
  • AHH
  • Ambeed
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Iris Biotech GmbH
  • IsoSciences
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
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  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-D0331-G010
  • Product description7-Dehydrocholesterol ≥95%(HPLC)
  • Packaging10g
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-07563
  • Product description7-Dehydrocholesterol 85%
  • Packaging1000g
  • Price$775
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA584741
  • Product description(3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95%
  • Packaging1g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA584741
  • Product description(3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95%
  • Packaging5g
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA584741
  • Product description(3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95%
  • Packaging25g
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA584741
  • Product description(3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95%
  • Packaging100g
  • Price$341
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA584741
  • Product description(3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95%
  • Packaging500g
  • Price$1293
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberLIP0020829
  • Product description5,7-CHOLESTADIEN-3-BETA-OL 95.00%
  • Packaging5MG
  • Price$453.27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM1046618
  • Product description7-DEHYDRO CHOLESTEROL 95.00%
  • Packaging25MG
  • Price$716.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM1046618
  • Product description7-DEHYDRO CHOLESTEROL 95.00%
  • Packaging250MG
  • Price$1686.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD165801
  • Product description7-Dehydrocholesterol - min95%
  • Packaging1g
  • Price$50
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberFD20900
  • Product description7-Dehydrocholesterol
  • Packaging5G
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD165801
  • Product description7-Dehydrocholesterol - min95%
  • Packaging2g
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD20900
  • Product description7-Dehydrocholesterol
  • Packaging10g
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD165801
  • Product description7-Dehydrocholesterol - min95%
  • Packaging5G
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD20900
  • Product description7-Dehydrocholesterol
  • Packaging25g
  • Price$165
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-D0331-G010 7-Dehydrocholesterol ≥95%(HPLC) 10g $76 2021-12-16 Buy
AHH MT-07563 7-Dehydrocholesterol 85% 1000g $775 2021-12-16 Buy
Ambeed A584741 (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95% 1g $10 2021-12-16 Buy
Ambeed A584741 (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95% 5g $32 2021-12-16 Buy
Ambeed A584741 (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95% 25g $105 2021-12-16 Buy
Ambeed A584741 (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95% 100g $341 2021-12-16 Buy
Ambeed A584741 (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 95% 500g $1293 2021-12-16 Buy
American Custom Chemicals Corporation LIP0020829 5,7-CHOLESTADIEN-3-BETA-OL 95.00% 5MG $453.27 2021-12-16 Buy
American Custom Chemicals Corporation CHM1046618 7-DEHYDRO CHOLESTEROL 95.00% 25MG $716.1 2021-12-16 Buy
American Custom Chemicals Corporation CHM1046618 7-DEHYDRO CHOLESTEROL 95.00% 250MG $1686.3 2021-12-16 Buy
Biosynth Carbosynth FD165801 7-Dehydrocholesterol - min95% 1g $50 2021-12-16 Buy
Biosynth Carbosynth FD20900 7-Dehydrocholesterol 5G $55 2021-12-16 Buy
Biosynth Carbosynth FD165801 7-Dehydrocholesterol - min95% 2g $80 2021-12-16 Buy
Biosynth Carbosynth FD20900 7-Dehydrocholesterol 10g $95 2021-12-16 Buy
Biosynth Carbosynth FD165801 7-Dehydrocholesterol - min95% 5G $125 2021-12-16 Buy
Biosynth Carbosynth FD20900 7-Dehydrocholesterol 25g $165 2021-12-16 Buy

Properties

Melting point :148-152 °C(lit.)
alpha :-116 º (C=1, CHCL3)
Boiling point :451.27°C (rough estimate)
Density :0.9717 (rough estimate)
refractive index :1.5100 (estimate)
storage temp. :-20°C
solubility :Chloroform (Sparingly), DMSO (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
form :Solid
pka :14.91±0.70(Predicted)
color :White to Yellow
optical activity :[α]20/D -115±8°, c = 1% in chloroform
Water Solubility :Insoluble
Merck :13,2887
BRN :2224615
Stability :Light Sensitive
InChIKey :UCTLRSWJYQTBFZ-DDPQNLDTSA-N
LogP :9.460 (est)
CAS DataBase Reference :434-16-2(CAS DataBase Reference)
NIST Chemistry Reference :Cholesta-5,7-dien-3-ol, (3«beta»)-(434-16-2)
EPA Substance Registry System :Cholesta-5,7-dien-3-ol, (3.beta.)- (434-16-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis from squalene. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS). 7-DHC is elevated in rats treated with the DHCR7 inhibitor AY9944, an animal model of SLOS. 7-DHC is subject to free radical oxidation (autoxidation), giving rise to several oxysterols which contribute to pathogenesis. Serum levels of 7-DHC, largely derived from the liver, are approximately 0.3 μM in healthy individuals. In the skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3 .