エホニジピン塩酸塩エタノール付加物
エホニジピン塩酸塩エタノール付加物 物理性質(zhì)
- 融點 :
- 151° (dec)
- 貯蔵溫度 :
- Inert atmosphere,2-8°C
- 溶解性:
- DMSO : 25 mg/mL (35.01 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- 外見 :
- Powder
- 色:
- Light yellow to yellow
安全性情報
- リスクと安全性に関する聲明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H361 |
生殖能または胎児への悪影響のおそれの疑い |
生殖毒性 |
2 |
警告 |
|
P201, P202, P281, P308+P313, P405,P501 |
|
| 注意書き |
| P201 |
使用前に取扱説明書を入手すること。 |
| P202 |
全ての安全注意を読み理解するまで取り扱わないこ と。 |
| P281 |
指定された個人用保護具を使用すること。 |
| P308+P313 |
暴露または暴露の懸念がある場合：醫(yī)師の診斷/手當てを 受けること。 |
| P405 |
施錠して保管すること。 |
| P501 |
內(nèi)容物/容器を．．．に廃棄すること。 |
|
エホニジピン塩酸塩エタノール付加物 価格
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
E0159 |
エホニジピン 塩酸塩 モノエタノラート ≥98% (HPLC)
≥98% (HPLC) |
111011-76-8 |
5MG |
￥22900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
E0159 |
エホニジピン 塩酸塩 モノエタノラート ≥98% (HPLC)
≥98% (HPLC) |
111011-76-8 |
25MG |
￥53100 |
2024-03-01 |
購入 |
エホニジピン塩酸塩エタノール付加物 化學特性,用途語,生産方法
効能
血圧降下薬, 血管拡張薬, カルシウムチャネル遮斷薬
商品名
ランデル (ゼリア新薬工業(yè)); ランデル (ゼリア新薬工業(yè))
説明
Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of
essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP)
calcium channel blocker to reach the market, it functions by binding to the DHP
receptors on voltage-dependent calcium channels to cause diuretic and natriuretic
actions in patients with essential hypertension. Its vasodilating and calcium
antagonist effects are very slow in onset and long-lasting in all types of
experimentally hypertensive models and the agent is reported to exhibit an improved
side effect profile compared with other drugs of the same class. This may be
explained by the slow and long-lasting inhibition of transmembrane Ca
+2 uptake,
which is accompanied by its very slow binding to and dissociation from the DHP
receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may
suppress the development of atherosclerosis without affecting the plasma lipids.
Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been
reported.
使用
Efonidipine Hydrochloride Monoethanolate is a potent inhibitor of the L-type calcium channel.
生物活性
Selective blocker of L-type and T-type Ca 2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R (-) and S (+)-enantiomers displays different channel selectivity; S (+)-Efonidipine blocks L-type and T-type channels whereas R (-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.
エホニジピン塩酸塩エタノール付加物 上流と下流の製品情報
原材料
準備製品
エホニジピン塩酸塩エタノール付加物 生産企業(yè)
Global( 90)Suppliers
エホニジピン塩酸塩エタノール付加物 スペクトルデータ(1HNMR)
111011-76-8(エホニジピン塩酸塩エタノール付加物)キーワード:
- 111011-76-8
- Efonidipine hydrochloride monoethanolate
- Efonidipine Hydrochloride ethanol (1:1:1)
- 2-(phenyl(phenylmethyl)amino)ethyleste
- 3-pyridinecarboxylicacid,1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxa
- efonidipinehydrochlorideethanolate
- nz-105
- nz105ethanolate
- r,p-oxide,monohydrochloride
- 5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylicacid2-[phenyl(phenylmethyl)amino]ethylesterhydrochloridemonoethanolate
- Hydrochloride ethanol
- NZ-105 HYDROCHLORIDE MONOETHANOLATE
- EFONIDIPINE USP/EP/BP
- Ethanol, compd. with 2-(phenyl(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide monohydrochloride (1:1)
- 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate compound with ethanol (1:1) hydrochloride
- 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride
- inhibit,Efonidipine hydrochloride monoethanolate,Ca channels,Ca2+ channels,Calcium Channel,Inhibitor
- 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride, compd. with ethanol (1:1:1)
- エホニジピン塩酸塩エタノール付加物
- エホニジピン塩酸塩エタノール付加物 (JAN)