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5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one

化學構(gòu)造式
1632125-79-1
CAS番號.
1632125-79-1
化學名:
別名:
英語名:
5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one
英語別名:
5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one;5-fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one;1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-
CBNumber:
CB93146773
化學式:
C21H22FN3O5S2
分子量:
479.54
MOL File:
1632125-79-1.mol

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one 物理性質(zhì)

沸點 :
711.7±70.0 °C(Predicted)
比重(密度) :
1.481±0.06 g/cm3(Predicted)
貯蔵溫度 :
Store at -20°C
溶解性:
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 1 mg/ml
外見 :
A crystalline solid
酸解離定數(shù)(Pka):
1.49±0.40(Predicted)
色:
White to off-white

安全性情報

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one 価格

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one 化學特性,用途語,生産方法

説明

Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer’s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.

使用

ML345 is a small molecule inhibitor of the insulin-degrading enzyme (IDE).

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one 上流と下流の製品情報

原材料

準備製品

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one 生産企業(yè)

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  • 1632125-79-1
  • 5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one
  • 5-fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one
  • 1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-
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