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2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸

2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸 化學(xué)構(gòu)造式
1572936-83-4
CAS番號(hào).
1572936-83-4
化學(xué)名:
2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸
別名:
2-[(4-メトキシナフタレン-2-イル)アミノ]-5-ニトロ安息香酸;2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸
英語(yǔ)名:
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
英語(yǔ)別名:
Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
CBNumber:
CB63049204
化學(xué)式:
C18H14N2O5
分子量:
338.31
MOL File:
1572936-83-4.mol

2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸 物理性質(zhì)

沸點(diǎn) :
553.1±50.0 °C(Predicted)
比重(密度) :
1.421±0.06 g/cm3(Predicted)
貯蔵溫度 :
Store at -20°C
溶解性:
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
外見(jiàn) :
A crystalline solid
酸解離定數(shù)(Pka):
2.26±0.22(Predicted)
色:
Brown to dark brown

安全性情報(bào)

2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸 価格

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購(gòu)入

2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸 化學(xué)特性,用途語(yǔ),生産方法

説明

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

使用

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸 生産企業(yè)

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  • 1572936-83-4
  • 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
  • 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
  • Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
  • Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel
  • 2-[(4-メトキシナフタレン-2-イル)アミノ]-5-ニトロ安息香酸
  • 2-(4-メトキシ-2-ナフチルアミノ)-5-ニトロ安息香酸
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