6-クロロニコチン酸
6-クロロニコチン酸 物理性質(zhì)
- 融點(diǎn) :
- 190 °C (dec.)(lit.)
- 沸點(diǎn) :
- 241.15°C (rough estimate)
- 比重(密度) :
- 0.5
- 屈折率 :
- 1.5870 (estimate)
- 閃點(diǎn) :
- 192°C
- 貯蔵溫度 :
- Keep in dark place,Sealed in dry,Room Temperature
- 溶解性:
- 脫イオン水: 可溶
- 外見 :
- 結(jié)晶性粉末
- 酸解離定數(shù)(Pka):
- 3.24±0.10(Predicted)
- 色:
- オフホワイトからベージュ
- 水溶解度 :
- 水（20℃で2mg/ml）、エタノール、メタノール、DMSOに溶け、クロロホルムに溶けにくい。
- Decomposition :
- 192 ºC
- BRN :
- 115993
- 安定性：:
- 安定。強(qiáng)力な酸化剤とは相容れない。
- InChIKey:
- UAWMVMPAYRWUFX-UHFFFAOYSA-N
- CAS データベース:
- 5326-23-8(CAS DataBase Reference)
- NISTの化學(xué)物質(zhì)情報(bào):
- 6-Chloronicotinic acid(5326-23-8)
- EPAの化學(xué)物質(zhì)情報(bào):
- 6-Chloronicotinic acid (5326-23-8)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01ACSP-1267S |
6-クロロピリジン-3-カルボン酸
6-Chloropyridine-3-carboxylic acid, 100 ug/mL in Methanol |
5326-23-8 |
1mL |
￥9800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01ACSP-1267N |
6-クロロピリジン-3-カルボン酸
6-Chloropyridine-3-carboxylic acid |
5326-23-8 |
10mg |
￥9800 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
C1116 |
6-クロロニコチン酸 >98.0%(T)
6-Chloronicotinic Acid
>98.0%(T) |
5326-23-8 |
25g |
￥7900 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
C1116 |
6-クロロニコチン酸 >98.0%(T)
6-Chloronicotinic Acid
>98.0%(T) |
5326-23-8 |
100g |
￥23400 |
2024-03-01 |
購入 |
|
関東化學(xué)株式會社(KANTO)
|
16869-2A |
６‐クロロニコチン酸 99%
6‐Chloronicotinic acid 99% |
5326-23-8 |
25g |
￥14630 |
2024-07-01 |
購入 |
6-クロロニコチン酸 化學(xué)特性,用途語,生産方法
外観
白色～うすい褐色、結(jié)晶性粉末～粉末
溶解性
エタノール及び水酸化ナトリウム溶液に溶け、水に溶けにくい。
用途
有機(jī)合成原料。
化學(xué)的特性
Off-white to beige crystalline powder
使用
6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.
定義
ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid.
一般的な説明
6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management.
合成
In a 1000ml flask, add 450g chlorobenzene, 100g 2-chloro-5-methylpyridine, and 3g catalyst cobalt acetate under stirring, heat the system to 80℃, introduce oxygen, and control the oxygen flow rate at 0.4L/min. React under this condition for 4 hours. After the reaction, cool the system to room temperature, filter, and dry to obtain a mixture of 119g 6-chloronicotinic acid and cobalt acetate. Place those mentioned above mixed crude product in a 1000ml flask, add 600g of recrystallization solvent methanol, stir and heat to reflux; wait for the 6-chloronicotinic acid crude product to dissolve completely, keep warm for 5min, slowly cool the system to 5℃, precipitate a white product, maintain this internal temperature and continue stirring for 1 hour, filter, wash the filter cake once with a small amount of cooled methanol, and dry the obtained damp product at 80℃ for 4 hours to obtain 98.5g 6-chloronicotinic acid, purity 99.52% (HPLC), yield 79.7%.
純化方法
Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.]
6-クロロニコチン酸 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
6-クロロニコチン酸 生産企業(yè)
Global( 672)Suppliers
6-クロロニコチン酸 スペクトルデータ(1HNMR、IR1、IR2、MS、Raman)
5326-23-8(6-クロロニコチン酸)キーワード:
- 5326-23-8
- 6-Chloronicotinic acid, 6-Chloropyridine-3-carboxylic acid
- 3-Carboxy-6-chloropyridine
- 6-Chloronicotinic acid ,97%
- 6-Chloropyridine-3-carboxylic acid,6-Chloronicotinic acid
- 6-Chloronicotinic ac
- RARECHEM AL BO 0729
- TIMTEC-BB SBB004004
- 3-Pyridinecarboxylic acid, 6-chloro-
- 6-chloro-3-pyridinecarboxylicaci
- 6-CHLORONICOTINIC ACID
- 6-CHLORO-3-PYRIDINECARBOXYLIC ACID
- 6-Chloronicotinic acid, 99% 25GR
- 6-Chloronicotinic acid, 99% 5GR
- 2-chloro-5-pyridincarboxylic acid
- 2-chloro-5-pyridineforMic acid
- 6-chloro-3-pyridincarboxylic acid
- 6-chloro-3-pyridineforMic acid
- 6-Chloropyridine-3-carboxylic acid, 5-Carboxy-2-chloropyridine
- 6-Chloronicotiinic acid
- 6-Chloro nicotintic acid
- 6-Chloropyridine-3-carboxylic acid 99%
- 6 - chlorine niacin
- 6-Chloronicoti
- 2-Chloroncotinic acid
- 6-Chloronicotinicacid,99%
- 6-chloro-3-carboxylic acid
- 6-Cholre Nicotinic Acid
- 6-Chloronicotinic acid 98%
- 6-CHLORO-3-PYRIDINECARBOXYLIC ACID / 6-CHLORONICOTINIC ACID
- 6-CHLORO NICOTINIC ACID 6-CHLORO NICOTINIC ACID
- 6-クロロニコチン酸
- 6-クロロ-3-ピリジンカルボン酸
- 6-クロロピリジン-3-カルボン酸
- 6クロロニコチン酸
- 6‐クロロニコチン酸
- 6‐クロロニコチン酸標(biāo)準(zhǔn)品
- 6-クロロニコチン酸標(biāo)準(zhǔn)品
- 6-クロロピリジン-3-カルボン酸, 100 μg/mL in Methanol
- 2-クロロピリジン-5-カルボン酸
- 2-クロロ-5-ピリジンカルボン酸
- クロロピリジン
- ハロピリジン
- 構(gòu)造分類