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N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide

化學(xué)構(gòu)造式
1346528-50-4
CAS番號(hào).
1346528-50-4
化學(xué)名:
別名:
英語(yǔ)名:
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
英語(yǔ)別名:
CS-2830;JNJ42165279;JNJ-42165279 (JNJ-5279);JNJ 42165279;JNJ42165279;JNJ-42165279, 10 mM in DMSO;Fatty acid amide hydrolase,inhibit,Autophagy,JNJ 42165279,FAAH,JNJ-42165279,Inhibitor;N-(4-Chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-;N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
CBNumber:
CB32671063
化學(xué)式:
C18H17ClF2N4O3
分子量:
410.8
MOL File:
1346528-50-4.mol

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide 物理性質(zhì)

沸點(diǎn) :
541.2±50.0 °C(Predicted)
比重(密度) :
1.52±0.1 g/cm3(Predicted)
貯蔵溫度 :
Store at -20°C
溶解性:
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
外見(jiàn) :
crystalline solid
酸解離定數(shù)(Pka):
12.91±0.20(Predicted)
色:
White to off-white

安全性情報(bào)

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide 価格

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購(gòu)入

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide 化學(xué)特性,用途語(yǔ),生産方法

説明

JNJ-42165279 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 70 and 313 nM for human and rat forms, respectively). It displays selectivity for FAAH over a panel of other enzymes, receptors, transporters, and ion channels. JNJ-42165279 is active in vivo, blocking FAAH activity in brain and periphery of rats and raising concentrations of anandamide , oleoyl ethanolamide , and palmitoyl ethanolamide . It is also efficacious in the spinal nerve ligation model of neuropathic pain.

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide 生産企業(yè)

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1346528-50-4()キーワード:

  • 1346528-50-4
  • N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
  • N-(4-Chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-1-piperazinecarboxamide
  • JNJ42165279
  • CS-2830
  • JNJ 42165279;JNJ42165279
  • 1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-
  • JNJ-42165279 (JNJ-5279)
  • Fatty acid amide hydrolase,inhibit,Autophagy,JNJ 42165279,FAAH,JNJ-42165279,Inhibitor
  • JNJ-42165279, 10 mM in DMSO
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