(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione
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(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 物理性質(zhì)
- 融點 :
- 158-159℃
- 沸點 :
- 604.6±55.0 °C(Predicted)
- 比重(密度) :
- 1.550±0.06 g/cm3(Predicted)
- 酸解離定數(shù)(Pka):
- 7.92±0.60(Predicted)
安全性情報
HSコード | 2922500090 |
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(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 価格
メーカー | 製品番號 | 製品説明 | CAS番號 | 包裝 | 価格 | 更新時間 | 購入 |
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(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 化學特性,用途語,生産方法
使用
(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione can be used as organic synthesis intermediates and pharmaceutical intermediates. It is an intermediate in the synthesis of amrubicin. amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer.合成
A mixture of R-9-acetamido-9- [1,1- (2,2-dimethylpropanedioxy) ethyl] -4,5-dihydro-6,13-dihydroxy -4,14- Methyl-14H-anthraceno [3,2-f] - [1,3] oxazolene-7,12-dione (Compound 4, R = CH3), 1200 g of 3N sulfuric acid aqueous solution and incubated at 60-70 ?? C for 8 hours. The pH of the solution was adjusted to 7-8 with aqueous sodium hydrogencarbonate solution, The combined chloroform layers were washed with water, dried, filtered and concentrated. The residue was stirred with isopropyl ether to give (+) - 9-amino-4-demethoxy-9-deoxo daunomycinone.
(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 上流と下流の製品情報
原材料
準備製品
(7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione 生産企業(yè)
Global( 14)Suppliers
名前 | 電話番號 | 電子メール | 國籍 | 製品カタログ | 優(yōu)位度 |
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Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 |
sophieliu@speranzachem.com | China | 802 | 55 |
Sense Chemicals (Shanghai) Co., Ltd. | +86-21-52751036; +8613818977689 |
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Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
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Hebei Weibang Biotechnology Co., Ltd | +8617732866630 |
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Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
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Wuhan EEChem Technologies Co., Ltd | 0711-3617768 13308685235 |
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Abydos Scientific | 025-84767922 18936879710 |
sales@abydoscientific.com | China | 1007 | 58 |
Speranza Chemical Co., Ltd. | 0755-21030354 18126410231 |
sales@speranzachem.com | China | 511 | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 |
czbjpharma@126.com | China | 18478 | 58 |
WEITIXIHAUGONG | 0371-53370800 18037197114 |
2853031799@qq.com | China | 9998 | 58 |
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- (7S,9S)-9-Acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-5,12-naphthacenedione
- Amrubicinhydrochloride int5
- 5,12-Naphthacenedione, 9-acetyl-9-amino-7,8,9,10-tetrahydro-6,7,11-trihydroxy-, (7S,9S)-
- 9α-amino-9β-acetyl-7,8,9,10-tetrahydro-6,7α,11-trihydroxy-5,12-naphthacenedione
- Amrubicin intermediate
- Amrubicin Intermediate 5
- (7S,9S)-9-Acetyl-9-amino-6,7,11-trihydroxy-7,8,9,10-tetrahydro-5,12-tetracenedione