Mirin
Mirin 物理性質(zhì)
- 融點 :
- 295-297 °C(Solv: ethanol (64-17-5))
- 沸點 :
- 441.6±55.0 °C(Predicted)
- 比重(密度) :
- 1.49±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- 2-8°C
- 溶解性:
- DMSO：>10mg/mL
- 外見 :
- 赤みがかったオレンジ色の粉末
- 酸解離定數(shù)(Pka):
- 9.15±0.30(Predicted)
- 色:
- 赤からオレンジ
- Sensitive :
- Moisture Sensitive
- 安定性：:
- 購入日から2年間安定です。この DMSO 溶液は、-20°C で 3 か月間保存できます。
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01FLC448141 |
5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one |
299953-00-7 |
250mg |
￥88100 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01FLC448141 |
5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one |
299953-00-7 |
500mg |
￥148100 |
2021-03-23 |
購入 |
|
Sigma-Aldrich Japan
|
M9948 |
≥98% (HPLC), powder
Mirin ≥98% (HPLC), powder |
299953-00-7 |
5mg |
￥21900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
M9948 |
≥98% (HPLC), powder
Mirin ≥98% (HPLC), powder |
299953-00-7 |
25mg |
￥65700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會社(wako)
|
W01FLC448141 |
5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one |
299953-00-7 |
1g |
￥250600 |
2021-03-23 |
購入 |
Mirin 化學(xué)特性,用途語,生産方法
説明
Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM). It inhibits phosphorylation of H2AX induced by DNA containing dsDNA breaks (DSBs), indicating decreased ATM activation, with an IC
50 value of 66 μM in
X. laevis cell-free extracts. Mirin (100 μM) also inhibits the exonuclease activity of Mre11 in a cell-free assay. It induces cell cycle arrest at the G
2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner. Nanoparticle-encapsulated mirin (50 mg/kg) reduces tumor growth in an LA-N-5 mouse xenograft model.
使用
The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical]
Biochem/physiol Actions
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.
Mirin 上流と下流の製品情報
原材料
準(zhǔn)備製品
Mirin 生産企業(yè)
Global( 32)Suppliers
299953-00-7()キーワード:
CHK2インヒビターII 水和物
3,5,7,8-テトラヒドロ-2-[4-(トリフルオロメチル)フェニル]-4H-チオピラノ[4,3-d]ピリミジン-4-オン
2,7-ビス[(3-フェニルプロピル)アミノ]-9H-フルオレン-9-オン
プロベネシド
6-[(E)-3,7-ジメチル-2,6-オクタジエニル]-2,3-ジメトキシ-5-メチル-1,4-ベンゾキノン
(3R)-3α,4β,5-トリメチル-6-オキソ-8-ヒドロキシ-3,4-ジヒドロ-6H-2-ベンゾピラン-7-カルボン酸
ジシアノメタノンm-クロロフェニルヒドラゾン
デシルウビキノン
2-[2-[4-(トリフルオロメトキシ)フェニル]ヒドラゾノ]プロパンジニトリル
- 299953-00-7
- 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
- MRN-ATM Pathway Inhibitor, Mirin
- (5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
- (E)-5-(4-hydroxybenzylidene)-2-iminothiazolidin-4-one
- 4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-
- Mirin >=98% (HPLC), powder
- Mirin, MRN-ATM complex inhibitor