Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- CAS No.
- 71827-03-7
- Chemical Name:
- Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- Synonyms
- Ivermectin B1a;IvermectinH2B1a;Ivermectin B1a (>85%);Ivermectin Impurity 3;Dihydroavermectin B1a;22,23-dihydroavermectin B1a in Methanol;5-O-Demethyl-22,23-dihydroavermectin A1a;22,23-Dihydro-5-O-demethylavermectin A1a;Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin 2-epimer (Dihydro Avermectin B1a)
- CBNumber:
- CB9928288
- Molecular Formula:
- C48H74O14
- Molecular Weight:
- 875.09
- MDL Number:
- MOL File:
- 71827-03-7.mol
- MSDS File:
- SDS
| Melting point | 155-157° |
|---|---|
| Boiling point | 717.97°C (rough estimate) |
| Density | 1.0683 (rough estimate) |
| refractive index | 1.6130 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 12.42±0.70(Predicted) |
| color | white |
| FDA UNII | 91Y2202OUW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
Avermectin A1a, 5-O-demethyl-22,23-dihydro- price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18768 | Ivermectin B1a ≥95% | 71827-03-7 | 5mg | $127 | 2024-03-01 | Buy |
| Cayman Chemical | 18768 | Ivermectin B1a ≥95% | 71827-03-7 | 25mg | $567 | 2024-03-01 | Buy |
| ApexBio Technology | C3905 | IvermectinB1a | 71827-03-7 | 25mg | $618 | 2021-12-16 | Buy |
| ApexBio Technology | C3905 | IvermectinB1a | 71827-03-7 | 5mg | $138 | 2021-12-16 | Buy |
| ChemScene | CS-0108408 | IvermectinB1a ≥99.0% | 71827-03-7 | 5mg | $450 | 2021-12-16 | Buy |
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Chemical Properties,Uses,Production
Description
Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.
Uses
Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Definition
ChEBI: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.
References
[1] j. wolsetnholme and a. t. rogers. glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. parasitology131 suppl, s85-s95 (2005).
[2] s. gaisser, l. kellenberger, a. l. kaja, et al. direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of streptomyces avermitilis atcc31272. organic & biomolecular chemistry 1(16), 2840-2847 (2003).
[3] j. p. arena, k. k. liu, p. s. paress, et al. the mechanism of action of avermectins in caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. journal of parasitology 81, 286-294 (1995).
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39004 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Moxin Chemicals | +8617320513646 | mike@molcoo.com | China | 9460 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | ORDERS@QCSRM.COM | China | 24342 | 58 |
| Guangzhou PI PI Biotech Inc | 020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3633 | 55 |
| BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5653 | 65 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18070 | 56 |
View Lastest Price from Avermectin A1a, 5-O-demethyl-22,23-dihydro- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Ivermectin B1a
71827-03-7
|
US $143.00-482.00 / mg | ≥98% | 10g | TargetMol Chemicals Inc. |
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- Ivermectin B1a
71827-03-7
- US $143.00-482.00 / mg
- ≥98%
- TargetMol Chemicals Inc.