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ChemicalBook >> CAS DataBase List >>AZ 12216052

AZ 12216052

CAS No.
1290628-31-7
Chemical Name:
AZ 12216052
Synonyms
AZ 12216052;AZ12216052 >=98% (HPLC);2-((4-Bromobenzyl)thio)-N-(4-(sec-butyl)phenyl)acetamide;2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide;Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-
CBNumber:
CB93146258
Molecular Formula:
C19H22BrNOS
Molecular Weight:
392.35308
MDL Number:
MFCD20926426
MOL File:
1290628-31-7.mol
Last updated:2024-11-17 16:00:36

AZ 12216052 Properties

Boiling point 526.9±45.0 °C(Predicted)
Density 1.323±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble
form A crystalline solid
pka 13.70±0.70(Predicted)
color White to off-white

AZ 12216052 price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29460 AZ 12216052 1290628-31-7 5mg $104 2024-03-01 Buy
Cayman Chemical 29460 AZ 12216052 1290628-31-7 25mg $412 2024-03-01 Buy
Cayman Chemical 29460 AZ 12216052 1290628-31-7 1mg $38 2024-03-01 Buy
Cayman Chemical 29460 AZ 12216052 1290628-31-7 10mg $184 2024-03-01 Buy
Tocris 4832 AZ12216052 ≥97%(HPLC) 1290628-31-7 10 $170 2021-12-16 Buy
Product number Packaging Price Buy
29460 5mg $104 Buy
29460 25mg $412 Buy
29460 1mg $38 Buy
29460 10mg $184 Buy
4832 10 $170 Buy

AZ 12216052 Chemical Properties,Uses,Production

Description

AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.

Uses

AZ 12216052 is a positive allosteric modulator of mGluR8, which are attractive therapeutic targets for anxiety disorders.

AZ 12216052 Preparation Products And Raw materials

Raw materials

Preparation Products

AZ 12216052 Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9804 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9014 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44811 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24641 58

View Lastest Price from AZ 12216052 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZ12216052 pictures 2024-11-17 AZ12216052
1290628-31-7
 US $52.00-198.00 / mg 99.29% 10g TargetMol Chemicals Inc.
  • AZ12216052 pictures
  • AZ12216052
    1290628-31-7
  • US $52.00-198.00 / mg
  • 99.29%
  • TargetMol Chemicals Inc.
AZ 12216052 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide AZ12216052 >=98% (HPLC) Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]- 2-((4-Bromobenzyl)thio)-N-(4-(sec-butyl)phenyl)acetamide 1290628-31-7