成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> CAS DataBase List >>SAR 131675

SAR 131675

CAS No.
1433953-83-3
Chemical Name:
SAR 131675
Synonyms
CS-994;SAR 131675 USP/EP/BP;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-
CBNumber:
CB92666683
Molecular Formula:
C18H22N4O4
Molecular Weight:
358.39
MDL Number:
MOL File:
1433953-83-3.mol
Last updated:2024-11-18 17:01:59

SAR 131675 Properties

Boiling point 592.2±50.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility insoluble in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 12.20±0.29(Predicted)
color White to yellow

SAR 131675 price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28385 SAR131675 1433953-83-3 1mg $32 2024-03-01 Buy
Cayman Chemical 28385 SAR131675 1433953-83-3 25mg $343 2024-03-01 Buy
Cayman Chemical 28385 SAR131675 1433953-83-3 5mg $122 2024-03-01 Buy
Cayman Chemical 28385 SAR131675 1433953-83-3 10mg $169 2024-03-01 Buy
Activate Scientific AS10294 SAR131675 90+% ee 1433953-83-3 25mg $170 2021-12-16 Buy
Product number Packaging Price Buy
28385 1mg $32 Buy
28385 25mg $343 Buy
28385 5mg $122 Buy
28385 10mg $169 Buy
AS10294 25mg $170 Buy

SAR 131675 Chemical Properties,Uses,Production

Characteristics

SAR131675 is a potent and selective VEGFR-3 tyrosine kinase inhibitor

Biological Activity

sar131675 is a selective inhibitor of vegfr-3 with ic50 value of 20nm [1].sar131675 is an atp-competitive inhibitor. it inhibits recombinant human vegfr-3 with ic50 value of 23nm and inhibits the kinase activity of vegfr-3 with ki value of 12nm. sar131675 is found to be cell permeable and inhibits vegfr-3 autophosphorylation in hek cells with ic50 values ranging from 30nm to 50nm. sar131675 shows ic50 values of >3μm and 235nm against vegfr-1 and vegfr-2, respectively. it also havs no inhibitory effect on a panel of 65 kinases, 107 nonkinase enzymes and receptors and on 21 ion channels. moreover, sar131675 inhibits lymphatic cell survival induced by vegfc and vegfd with ic50 values of 14nm and 17nm. on another hand, sar131675 exerts inhibition of the migration induced by vegfa or vegfc with ic50 values of 100nm and <30nm in hlmvec cells, respectively [1]..

in vitro

SAR131675 inhibits the proliferation of primary human lymph node cells induced by VEGFR-3 ligands VEGFC and VEGFD in a dose-dependent manner with IC50 of approximately 20 nM, and also inhibits the activity of rh-VEGFR-3–TK in a dose-dependent manner characteristic, IC50 of 23 nM. SAR131675 inhibits VEGFR-1–TK activity with IC50 greater than 3 μM and inhibits VEGFR-2–TK activity with IC50 of 235 nM.

in vivo

sar131675 abrogates lymphangiogenesis and angiogenesis induced by fgf2. it also shows antitumor activity in the mice models. treatment with sar131675 significantly reduces the tumor volume of 4t1 mammary carcinoma tumors [1]

target

VEGFR3

References

[1] alam a, blanc i, gueguen-dorbes g, et al. sar131675, a potent and selective vegfr-3–tk inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. molecular cancer therapeutics, 2012, 11(8): 1637-1649.

SAR 131675 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32112 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38596 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58

View Lastest Price from SAR 131675 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SAR131675 pictures 2024-11-18 SAR131675
1433953-83-3
 US $30.00-115.00 / mg 99.68% 10g TargetMol Chemicals Inc.
  • SAR131675 pictures
  • SAR131675
    1433953-83-3
  • US $30.00-115.00 / mg
  • 99.68%
  • TargetMol Chemicals Inc.

SAR 131675 Spectrum

(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo- CS-994 SAR 131675 USP/EP/BP (R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide 1433953-83-3 Inhibitors API