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ChemicalBook >> CAS DataBase List >>Saxagliptin hydrate

Saxagliptin hydrate

CAS No.
945667-22-1
Chemical Name:
Saxagliptin hydrate
Synonyms
CS-1180;Onglyza hydrate;BMS477118 hydrate;BMS-477118 hydrate;BMS 477118 hydrate;Saxagliptin hydrate;Shagliptin monohydrate;Saxagliptin hydrate Unii-9gb927lajw;Saxagliptin hydrate (BMS-477118 hydrate);BMS-477118 HYDRATE;BMS 477118 HYDRATE;BMS477118 HYDRATE
CBNumber:
CB92542796
Molecular Formula:
C18H27N3O3
Molecular Weight:
333.43
MDL Number:
MOL File:
945667-22-1.mol
MSDS File:
SDS
Last updated:2024-11-06 19:41:26

Saxagliptin hydrate Properties

Melting point 106-108°C
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Sparingly)
form Solid
color White to Off-White
FDA UNII 9GB927LAJW

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Saxagliptin hydrate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC S143750 SaxagliptinHydrate 945667-22-1 500mg $525 2021-12-16 Buy
Ark Pharm P000018464 Saxagliptin hydrate 99+% 945667-22-1 100mg $567 2021-12-16 Buy
Biorbyt Ltd orb611536 Saxagliptin hydrate 945667-22-1 250mg $615.4 2021-12-16 Buy
Ark Pharm P000018464 Saxagliptin hydrate 99+% 945667-22-1 50mg $349 2021-12-16 Buy
AK Scientific Z6180 Saxagliptinhydrate 945667-22-1 50mg $385 2021-12-16 Buy
Product number Packaging Price Buy
S143750 500mg $525 Buy
P000018464 100mg $567 Buy
orb611536 250mg $615.4 Buy
P000018464 50mg $349 Buy
Z6180 50mg $385 Buy

Saxagliptin hydrate Chemical Properties,Uses,Production

Description

While liraglutide targets the incretin system as a GLP-1 analog for therapeutic intervention in T2DM, saxagliptin enhances GLP-1 plasma concentrations by inhibiting the DPP-4 enzyme responsible for degradation of GLP-1 by cleavage of the two N-terminal amino acids adjacent to alanine (or proline), thereby rendering the hormone inactive. Similarto vildagliptin, saxagliptin is a cyanopyrrolidine substrate-based inhibitor. The proline mimetic occupies the small S1-pocket while the nitrile’s trajectory aligns with the scissile bond of the substrate. The slow dissociation kinetics of saxagliptin is attributed to a reversible, covalent reaction between the nitrile and the catalytically active serine hydroxyl (Ser630). The steric bulk provided by the adamantyl moiety and the constrained cyclopropyl ring stabilizes the trans-rotamer of the amide, thereby preventing the problematic intramolecular cyclization, via the amino group attacking the nitrile, which is favored in the cis-conformation.
Since metabolism of saxagliptin is primarily mediated by CYP3A4/5, there is a potential for drug interactions with concomitant administration of strong inducers or inhibitors of these cytochrome P450 enzymes. The most common adverse events (>5% of patients) included upper respiratory tract infection, urinary tract infection, and headache.

Originator

Bristol-Myers-Squibb (US)

Uses

Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.

Definition

ChEBI: Saxagliptin hydrate is a hydrate that is the monohydrate form of anhydrous saxagliptin. Used for the treatment of Type II diabetes. It has a role as a hypoglycemic agent and an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor. It contains a saxagliptin.

brand name

Onglyza

Biological Activity

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

Solubility in organics

Saxagliptin hydrochloride is supplied as a crystalline solid. A stock solution may be made by dissolving the saxagliptin (hydrochloride)in the solvent of choice,which should be purged with an inert gas. Saxagliptin hydrochloride is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of saxagliptin hydrochloride in these solvents is approximately 10 mg/ml in ethanol and 20 mg/ml in DMSO and DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of saxagliptin(hydrochloride)can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of saxagliptin (hydrochloride)in PBS(pH 7.2), is approximately 2 mg/ml. We do not recommend storing the aqueous solution for more than one day.

Saxagliptin hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 183)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21638 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32070 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10319 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15356 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 info@fortunachem.com China 5986 58

View Lastest Price from Saxagliptin hydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Saxagliptin hydrate pictures 2024-11-06 Saxagliptin hydrate
945667-22-1
 US $40.00-93.00 / mg 99.8% 10g TargetMol Chemicals Inc.
Saxagliptin hydrate pictures 2024-11-06 Saxagliptin hydrate
945667-22-1
 US $40.00-93.00 / mg 99.8% 10g TargetMol Chemicals Inc.
Saxagliptin hydrate pictures 2022-09-23 Saxagliptin hydrate
945667-22-1
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

Saxagliptin hydrate Spectrum

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, hydrate (1:1), (1S,3S,5S)- Saxagliptin hydrate Saxagliptin hydrate Unii-9gb927lajw (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate Saxagliptin hydrate (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate CS-1180 BMS 477118 hydrate BMS477118 hydrate BMS-477118 hydrate BMS-477118 HYDRATE;BMS 477118 HYDRATE;BMS477118 HYDRATE Saxagliptin hydrate (BMS-477118 hydrate) Onglyza hydrate (1S,3S,5S)-2-((2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile Saxagliptin MonohydrateQ: What is Saxagliptin Monohydrate Q: What is the CAS Number of Saxagliptin Monohydrate Q: What is the storage condition of Saxagliptin Monohydrate Q: What are the applications of Saxagliptin Monohydrate (1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrate 4-trifluorosulfoyl-3'-trifluoroacetamino-4-demethyldaunorubicin Shagliptin monohydrate 945667-22-1 C18H25N3O2H2O Saxagliptin hydrate API