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ChemicalBook >> CAS DataBase List >>3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

CAS No.
641571-11-1
Chemical Name:
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Synonyms
NILOTINIB IMPURITY 24;Nilotinib Intemediate 1;Nilotinib EP Impurity A;Nilotinib Amino Impurity;Nilotinib??Intermediates?A;Nilotinib genotoxic impurity 1;Nilotinib Hydrochloride Monohydrate Impurity A;Nilotinib Impurity 15(Nilotinib EP Impurity A);3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl);Nilotinib Hydrochloride Monohydrate EP Impurity A
CBNumber:
CB91503963
Molecular Formula:
C11H10F3N3
Molecular Weight:
241.21
MDL Number:
MFCD11846236
MOL File:
641571-11-1.mol
Last updated:2024-03-28 16:41:05

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Properties

Melting point 124-126°C
Boiling point 372.14℃[at 101 325 Pa]
Density 1.35
vapor pressure 0Pa at 25℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form powder to crystal
color White to Light gray to Light yellow
Water Solubility 228.6mg/L at 25℃
InChI InChI=1S/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
InChIKey WWTGXYAJVXKEKL-UHFFFAOYSA-N
SMILES C1(N2C=C(C)N=C2)C=C(N)C=C(C(F)(F)F)C=1
LogP 2.42
CAS DataBase Reference 641571-11-1(CAS DataBase Reference)
FDA UNII 5LLI0Q7APP

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H318
Precautionary statements  P280-P301+P310-P305+P351+P338
Risk Statements  41
Safety Statements  26-39
RIDADR  2811
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  2933299090

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich VBP00135 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1 1g $482 2024-03-01 Buy
TCI Chemical M2634 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T) 641571-11-1 1g $33 2024-03-01 Buy
TCI Chemical M2634 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T) 641571-11-1 5g $109 2024-03-01 Buy
TRC M313065 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline 641571-11-1 25mg $145 2021-12-16 Buy
SynQuest Laboratories 3H30-3-T2 3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride 641571-11-1 250mg $150 2021-12-16 Buy
Product number Packaging Price Buy
VBP00135 1g $482 Buy
M2634 1g $33 Buy
M2634 5g $109 Buy
M313065 25mg $145 Buy
3H30-3-T2 250mg $150 Buy

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Chemical Properties,Uses,Production

Description

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a pharmaceutical intermediate component used in the preparation of Nilotinib for the treatment of a variety of leukaemias, including chronic myeloid leukaemia (CML).

Chemical Properties

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a white to light grey to light yellow powder to crystals with a melting point of 130 °C.

Uses

Intermediate in the preparation of Nilotinib.

Application

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is an arylimidazole derivative. This compound includes multiple functional groups: aniline, methyl, and imidazole. Hence, the compound is readily available for further functionalization. This building block can typically synthesize homoleptic imidazole-type iridium (Ir) triplet emitters as a blue phosphorescent emitter in OLED. The iridium organometallic complex is formed by coordinating the imidazole and the aryl group to the iridium metal center. The trifluoromethyl group, with a strong electron-withdrawing effect, increases the energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital (HOMO-LUMO), hence enabling a blue shift in the photoluminescent emission[1].

References

[1] Qiang Wei. “Small-Molecule Emitters with High Quantum Efficiency: Mechanisms, Structures, and Applications in OLED Devices.” Advanced Optical Materials 6 20 (2018).

822-36-6
54962-75-3
641571-11-1
Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline from 4-Methylimidazole and 3-Amino-5-bromobenzotrifluoride
Global( 357)Suppliers
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Yangzhou Qinyuan Pharmatech Co.,ltd 		+86-18752526868 jennysun@yzqyyykj.com China 80 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20288 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
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Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21638 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9219 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
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Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58

View Lastest Price from 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(4-Methyl-1H-Imidazol-1-yl)-5-(Trifluoromethyl)Aniline pictures 2024-11-05 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Trifluoromethyl)Aniline
641571-11-1
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline pictures 2024-10-31 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
 US $0.00 / g 10g 99% 10tons Yangzhou Qinyuan Pharmatech Co.,ltd
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline pictures 2024-03-29 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
 US $35.00-1.20 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Nilotinib genotoxic impurity 1 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Nilotinib Intemediate 1 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl) benzene amine 3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine 3-(4-Methyl-iMidazol-1-yl)-5-trifluoro-MethylphenylaMine 3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzeneaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)aniline BenzenaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)- 3-(4-Methyl-iMidazole-1-yl)-5-trifluoro MethylphenylaMine 5-(4-Methyl-1H-iMidazol-1-yl)-3-(trifluoroMethyl)-BenzeneaMine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole Nilotinib Amino Impurity 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline > Nilotinib Related Compound A USP Impurity Certified Reference Standard 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoro methyl)benzamine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline(For export only) 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline ISO 9001：2015 REACH 3-(4-Methyl-1-imidazolyl)-5-(trifluoromethyl)aniline Nilotinib EP Impurity A NILOTINIB IMPURITY 24 3-(4-Methyl-1H-imidazol-1-yl)-5- (trifluoromethyl)aniline(Nilotinib EP Impurity A) Nilotinib??Intermediates?A Nilotinib Hydrochloride Monohydrate Impurity A 5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)benzenamine Nilotinib Impurity 15(Nilotinib EP Impurity A) 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Tri?uoromethyl)Aniline 5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-aniline 5- (4-methyl-1H-Imidazol-1-yl)3- (trifluoromethy benzenamine Nilotinib Hydrochloride Monohydrate EP Impurity A 641571-11-1 541571-11-1 Nilotinib/Tasigna Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals