CP-465022 (maleate)
- CAS No.
- 199656-46-7
- Chemical Name:
- CP-465022 (maleate)
- Synonyms
- CP-465022 (maleate);CP-392,110 (maleate);WLLUWLRVXIHECY-KSUUAYPFSA-N;3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone-(2Z)-2-butenedioate;CP-465022 Maleate, 3-(2-Chlorophenyl)-2-[2-[6- [(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro- 4(3H)-quinazolinone Maleate
- CBNumber:
- CB83167496
- Molecular Formula:
- C30H28ClFN4O5
- Molecular Weight:
- 579.03
- MDL Number:
- MFCD30533447
- MOL File:
- 199656-46-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
CP-465022 (maleate) price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20473 | CP-465,022 (maleate) | 199656-46-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20473 | CP-465,022 (maleate) | 199656-46-7 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 20473 | CP-465,022 (maleate) | 199656-46-7 | 10mg | $153 | 2024-03-01 | Buy |
| AK Scientific | SYN5257 | CP-465022Maleate | 199656-46-7 | 10mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | C4398 | CP-465022(maleate) | 199656-46-7 | 10mg | $173 | 2021-12-16 | Buy |
CP-465022 (maleate) Chemical Properties,Uses,Production
Biological Activity
cp-465022 is an ampa antagonist.the inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor has been hypothesized to lead to neuroprotective efficacy after cerebral ischemia on the basis of the activity in ischemia models of a variety of compounds with varying selectivity for ampa over other glutamate receptor subtypes.
in vitro
cp-465022 inhibited ampa receptor-mediated currents in rat cortical neurons and such inhibition was found to be noncompetitive with agonist concentration. cp-465022 was selective for ampa over kainate and n-methyl-d-aspartate receptors. however, cp-465022 was found to be equipotent for ampa receptors composed of different ampa receptor subunit combinations, which indicated that cp-465022 is equivalently potent for inhibition of ampa receptor-mediated responses in different types of neurons expressing different ampa receptor subunits [1].
in vivo
animal study showed that cp-465022 could potently and efficaciously inhibit ampa receptor-mediated hippocampal synaptic transmission and the induction of seizures. however, at comparable doses, cp-465022 failed to prevent ca1 neuron loss after brief global ischemia or to reduce infarct volume after temporary middle cerebral artery occlusion [2].
IC 50
25 nm for ampa receptor-mediated currents in rat cortical neurons
References
[1] lazzaro jt, paternain av, lerma j, chenard bl, ewing fe, huang j, welch wm, ganong ah, menniti fs. functional characterization of cp-465,022, a selective, noncompetitive ampa receptor antagonist. neuropharmacology. 2002 feb;42(2):143-53.
[2] menniti fs, buchan am, chenard bl, critchett dj, ganong ah, guanowsky v, seymour pa, welch wm. cp-465,022, a selective noncompetitive ampa receptor antagonist, blocks ampa receptors but is not neuroprotective in vivo. stroke. 2003 jan;34(1):171-6.
CP-465022 (maleate) Preparation Products And Raw materials
Raw materials
Preparation Products
CP-465022 (maleate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8617 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |
View Lastest Price from CP-465022 (maleate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | CP-465022 (maleate)
199656-46-7
|
US $78.00-383.00 / mg | 10g | TargetMol Chemicals Inc. |
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- CP-465022 (maleate)
199656-46-7
- US $78.00-383.00 / mg
- TargetMol Chemicals Inc.