ChemicalBook >> CAS DataBase List >>EFT-508
EFT-508
- CAS No.
- 1849590-01-7
- Chemical Name:
- EFT-508
- Synonyms
- EFT-508;CS-2450;eFT508 -MNK;Tomivosertib;eFT-508 (eFT508);Tomivosertib eFT508;eFT508(Tomivosertib);EFT 508;EFT-508;TOMIVOSERTIB;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
- CBNumber:
- CB83133222
- Molecular Formula:
- C17H20N6O2
- Molecular Weight:
- 340.38
- MDL Number:
- MFCD30489732
- MOL File:
- 1849590-01-7.mol
Last updated:2024-10-31 18:15:48
| Melting point | >300°C |
|---|---|
| Boiling point | 735.6±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | DMSO (Slightly, Heated), Methanol (Very Slightly) |
| pka | 13.77±0.60(Predicted) |
| form | Solid |
| color | Pale Yellow |
| FDA UNII | U2H19X4WBV |
| NCI Drug Dictionary | tomivosertib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
EFT-508 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21957 | eFT508 ≥98% | 1849590-01-7 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 21957 | eFT508 ≥98% | 1849590-01-7 | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 21957 | eFT508 ≥98% | 1849590-01-7 | 10mg | $535 | 2024-03-01 | Buy |
| Cayman Chemical | 21957 | eFT508 ≥98% | 1849590-01-7 | 25mg | $1002 | 2024-03-01 | Buy |
| TRC | A629153 | 6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione | 1849590-01-7 | 5mg | $150 | 2021-12-16 | Buy |
EFT-508 Chemical Properties,Uses,Production
Description
eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC50s = <10 nM). It inhibits phosphorylation of eukaryotic initiation factor 4E (eIF4E) with an IC50 value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.
Uses
6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor.
EFT-508 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 81)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32002 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38460 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from EFT-508 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-31 | Tomivosertib
1849590-01-7
|
US $59.00-255.00 / mg | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-09 | EFT-508
1849590-01-7
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- Tomivosertib
1849590-01-7
- US $59.00-255.00 / mg
- 99.67%
- TargetMol Chemicals Inc.
-
- EFT-508
1849590-01-7
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
1849590-01-7(EFT-508)Related Search:
EFT-508
6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione
eFT508 -MNK
6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione
Tomivosertib eFT508
CS-2450
EFT 508;EFT-508;TOMIVOSERTIB
6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl-
eFT508(Tomivosertib)
Tomivosertib
eFT-508 (eFT508)
6'-((6-Aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione
6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2',5'-dihydro-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione
6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
1849590-01-7
849590-01-7