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ChemicalBook >> CAS DataBase List >>GSK1292263

GSK1292263

CAS No.
1032823-75-8
Chemical Name:
GSK1292263
Synonyms
CS-417;GSK1292263;GSK1292263 USP/EP/BP;GSK-1292263;GSK 1292263;GPR119 receptor agonist GS1292263;GPR119 Agonist II GSK1292263 GSK-1292263;3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-;3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxa;5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-2-(4-(methylsulfonyl)phenyl)pyridine;3-isopropyl-5-(4-(((6-(4-(Methylsulfonyl)phenyl)pyridin-3-yl)oxy)Methyl)piperidin-1-yl)-1,2,4-oxadiazole
CBNumber:
CB82522975
Molecular Formula:
C23H28N4O4S
Molecular Weight:
456.56
MDL Number:
MFCD18385004
MOL File:
1032823-75-8.mol
MSDS File:
SDS
Last updated:2024-10-30 18:52:02

GSK1292263 Properties

Boiling point 655.1±65.0 °C(Predicted)
Density 1.23
storage temp. Store at -20°C
solubility ≥21.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form solid
pka 4.75±0.32(Predicted)
color White to off-white
FDA UNII R1J57STA6O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

GSK1292263 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26181 GSK1292263 1032823-75-8 5mg $119 2024-03-01 Buy
Cayman Chemical 26181 GSK1292263 1032823-75-8 50mg $813 2024-03-01 Buy
Cayman Chemical 26181 GSK1292263 1032823-75-8 10mg $214 2024-03-01 Buy
Cayman Chemical 26181 GSK1292263 1032823-75-8 25mg $501 2024-03-01 Buy
ChemScene CS-0228 GSK1292263 99.71% 1032823-75-8 10mg $150 2021-12-16 Buy
Product number Packaging Price Buy
26181 5mg $119 Buy
26181 50mg $813 Buy
26181 10mg $214 Buy
26181 25mg $501 Buy
CS-0228 10mg $150 Buy

GSK1292263 Chemical Properties,Uses,Production

Biological Activity

gsk1292263 is a novel agonist of gpr119 receptor agonist and is used for the treatment of type 2 diabetes.gpr119 is described as a class a (rhodopsin-type) orphan gpcr with no close primary sequence relative in the human genome. the activation of gpr119 increases the intracellular accumulation of camp, resulting in enhanced insulin secretion from pancreatic β-cells and increased release of the gut peptides glp-1 (glucagon-like peptide 1), gip (glucose-dependent insulinotropic peptide) and pyy (polypeptide yy).in vitro, gsk1292263 treatment displayed little inhibition towards cyps (cyp1a2, 2c9, 2c19, 2d6, 3a4), p-gp, oatp1b3, or oct2. however, gsk1292263 inhibited bcrp and oatp1b1, which are transporters involved in statin disposition 1.in the glucose tolerance test in rats, administration of gsk-1292263 significantly increases the peak insulin response and insulin auc (0-15 min) as compared with the values in the vehicle control. the upregulation of insulin was found to correlate with an increase in the glucose disposal rate. in hyperinsulinemic-euglycemic clamps, gsk-1292263 administration on sprague-dawley rats at dose of 10 or 30 mg/kg 2 hours prior to insulin infusion can promote glucagon secretion with no increase of blood glucose levels 2.

target

GPR119

References

1. polli jw, hussey e, bush m, et al. evaluation of drug interactions of gsk1292263 (a gpr119 agonist) with statins: from in vitro data to clinical study design. xenobiotica; the fate of foreign compounds in biological systems. 2013;43(6):498-508.2. zhu x, huang d, lan x, et al. the first pharmacophore model for potent g protein-coupled receptor 119 agonist. european journal of medicinal chemistry. 2011;46(7):2901-2907.

GSK1292263 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 111)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29886 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32002 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 23325 58

View Lastest Price from GSK1292263 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK1292263 pictures 2024-10-30 GSK1292263
1032823-75-8
 US $29.00-76.00 / mg 99.46% 10g TargetMol Chemicals Inc.
GSK1292263 pictures 2019-07-06 GSK1292263
1032823-75-8
 US $7.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • GSK1292263 pictures
  • GSK1292263
    1032823-75-8
  • US $29.00-76.00 / mg
  • 99.46%
  • TargetMol Chemicals Inc.
  • GSK1292263 pictures
  • GSK1292263
    1032823-75-8
  • US $7.00 / kg
  • 99%
  • Career Henan Chemical Co
3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4- 5-[[[1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methyl]oxy]-2-[4-(methylsulfonyl)phenyl]pyridine 3-isopropyl-5-(4-(((6-(4-(Methylsulfonyl)phenyl)pyridin-3-yl)oxy)Methyl)piperidin-1-yl)-1,2,4-oxadiazole 3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxa GSK1292263 5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-2-(4-(methylsulfonyl)phenyl)pyridine 5-[[[1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methyl]oxy]-2-[4-(methylsulfonyl)phenyl]pyridine gsk 1292263 CS-417 GPR119 receptor agonist GS1292263 GSK-1292263;GSK 1292263 Pyridine, 5-[[1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methoxy]-2-[4-(methylsulfonyl)phenyl]- GSK1292263 USP/EP/BP GPR119 Agonist II GSK1292263 GSK-1292263 1032823-75-8 Inhibitors