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ChemicalBook >> CAS DataBase List >>1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine

CAS No.
343787-29-1
Chemical Name:
1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine
Synonyms
CS-464;CP 673451;CP 673451; CP673451;CP-673451;CP 673451;CP673451;CP-673451 PDGFR Inhibitor CP673451;1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine;1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine;4-PiperidinaMine,1-[2-[5-(2-Methoxyethoxy)-1H-benziMidazol-1-yl]-8-quinolinyl]-;1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine;1-(2-(5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine
CBNumber:
CB72512526
Molecular Formula:
C24H27N5O2
Molecular Weight:
417.5
MDL Number:
MFCD11100329
MOL File:
343787-29-1.mol
MSDS File:
SDS
Last updated:2024-10-28 16:48:35

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine Properties

Boiling point 656.3±65.0 °C(Predicted)
Density 1.32
storage temp. Store at -20°C
solubility insoluble in H2O; ≥2.39 mg/mL in EtOH with gentle warming and ultrasonic; ≥20.9 mg/mL in DMSO
form Powder
pka 9.84±0.20(Predicted)
color White to off-white
FDA UNII 0AM0WWD90A

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3368 CP-673451 ≥95% (HPLC) 343787-29-1 10MG $112 2024-03-01 Buy
Sigma-Aldrich SML3368 CP-673451 ≥95% (HPLC) 343787-29-1 50MG $360 2024-03-01 Buy
Cayman Chemical 19170 CP 673,451 ≥98% 343787-29-1 1mg $44 2024-03-01 Buy
Cayman Chemical 19170 CP 673,451 ≥98% 343787-29-1 5mg $183 2024-03-01 Buy
Cayman Chemical 19170 CP 673,451 ≥98% 343787-29-1 10mg $278 2024-03-01 Buy
Product number Packaging Price Buy
SML3368 10MG $112 Buy
SML3368 50MG $360 Buy
19170 1mg $44 Buy
19170 5mg $183 Buy
19170 10mg $278 Buy

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine Chemical Properties,Uses,Production

Uses

1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine exhibits antiangiogenic and antitumor properties. It is an inhibitor of platelet-derived growth factor receptor β (PDGFR- β).

Uses

CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.

Definition

ChEBI: 1-[2-[5-(2-methoxyethoxy)-1-benzimidazolyl]-8-quinolinyl]-4-piperidinamine is an aminoquinoline.

Biological Activity

cp-673451 is a potent inhibitor of pdgfr with ic50 value of 10nm and 1nm for pdgfr-α and pdgfr-β, respectively [1].cp-673451 is an atp-competitive inhibitor and is investigated to treat for cancer. it is highly selective against pdgfr-α and pdgfr-β over a variety of other kinases such as vegfr-1, vegfr-2, lck, tie-2 and egfr. in pae-β cells, cp-673451 inhibits pdgfr-β with ic50 value of 6.4nm. cp-673451 also inhibits c-kit with ic50 value of 1.1μm in h526 cells. in rat c6 glioblastoma xenograft models, a single oral dose of 50mg/kg cp-673451 reduces > 50% phosphorylation of pdgfr-β for 4 hours. in addition, cp-673451 is found to inhibit pdgf-bb-induced angiogenesis in a sponge angiogenesis model. furthermore, cp-673451 inhibits the tumor growth in colo205, ls174t, h460, and u87mg xenograft models. it also reduces the microvessel density of colo205 xenografts [1].

target

PDGFRβ

storage

Store at -20°C

References

[1] roberts w g, whalen p m, soderstrom e, et al. antiangiogenic and antitumor activity of a selective pdgfr tyrosine kinase inhibitor, cp-673,451. cancer research, 2005, 65(3): 957-966.

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29886 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32002 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 23325 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9729 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58

View Lastest Price from 1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CP-673451 pictures 2024-10-28 CP-673451
343787-29-1
 US $44.00-97.00 / mg 99.93% 10g TargetMol Chemicals Inc.
1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine pictures 2019-08-08 1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine
343787-29-1
 US $3.00 / KG 1KG 99% 100kg Career Henan Chemical Co
  • CP-673451 pictures
  • CP-673451
    343787-29-1
  • US $44.00-97.00 / mg
  • 99.93%
  • TargetMol Chemicals Inc.

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine Spectrum

343787-29-1(1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine)Related Search:

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine CP 673451 1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine 4-PiperidinaMine,1-[2-[5-(2-Methoxyethoxy)-1H-benziMidazol-1-yl]-8-quinolinyl]- 1-(2-(5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine 1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine CP 673451 1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine CP 673451 CP-673451;CP 673451;CP673451 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine CP 673451; CP673451 CS-464 1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine USP/EP/BP CP-673451 PDGFR Inhibitor CP673451 343787-29-1 Inhibitors