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ChemicalBook >> CAS DataBase List >>S-Trityl-L-cysteine

S-Trityl-L-cysteine

CAS No.
2799-07-7
Chemical Name:
S-Trityl-L-cysteine
Synonyms
H-CYS(TRT)-OH;Dimethyl 5-bromopyridine-2,3-dicarboxylate;H-L-Cys(Trt)-OH;S-Tritylcysteine;H-Cys(Trt)-OH (Cys of Animal Origin);NSC 83265;L-Cys(Trt)-OH;CYSTEINE(TRT)-OH;EG5 INHIBITOR II;TRITYL-L-CYSTEINE
CBNumber:
CB7164332
Molecular Formula:
C22H21NO2S
Molecular Weight:
363.47
MDL Number:
MFCD00002611
MOL File:
2799-07-7.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33

S-Trityl-L-cysteine Properties

Melting point 182-183 °C (dec.)(lit.)
Boiling point 524.7±50.0 °C(Predicted)
Density 1.1342 (rough estimate)
refractive index 111 ° (C=0.8, 0.04mol Ethanolic HCl)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 20 mg/ml).
form White to off-white solid.
pka 2.22±0.10(Predicted)
color White or off-white
optical activity [α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
BRN 2339626
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
CAS DataBase Reference 2799-07-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25
WGK Germany  3
RTECS  AY7710000
HS Code  29309090
Toxicity dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993,
NFPA 704
1
1 0

S-Trityl-L-cysteine price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 164739 (+)-S-Trityl-L-cysteine 97% 2799-07-7 5g $185 2024-03-01 Buy
TCI Chemical T2522 S-Trityl-L-cysteine >95.0%(T) 2799-07-7 5g $49 2024-03-01 Buy
Alfa Aesar L14384 (+)-S-Trityl-L-cysteine 97% 2799-07-7 1g $25.2 2023-06-20 Buy
Alfa Aesar L14384 (+)-S-Trityl-L-cysteine 97% 2799-07-7 5g $57.6 2023-06-20 Buy
Cayman Chemical 23236 S-trityl-L-Cysteine ≥98% 2799-07-7 1g $25 2024-03-01 Buy
Product number Packaging Price Buy
164739 5g $185 Buy
T2522 5g $49 Buy
L14384 1g $25.2 Buy
L14384 5g $57.6 Buy
23236 1g $25 Buy

S-Trityl-L-cysteine Chemical Properties,Uses,Production

Description

S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.

Chemical Properties

almost white to light yellow granular powder

Uses

(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.

Uses

A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.

Definition

ChEBI: (2R)-2-amino-3-[(triphenylmethyl)thio]propanoic acid is a benzenoid aromatic compound.

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.

storage

Store at +4°C

References

1) DeBonis et al. (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities; Mol. Cancer Ther. 3 1079 2) Brier et al. (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5; Biochemistry 43 13072 3) Skoufias et al. (2006) S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression; J. Biol. Chem., 281 17559

S-Trityl-L-cysteine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 259)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 11818 58

View Lastest Price from S-Trityl-L-cysteine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
S-trityl-L-Cysteine pictures 2024-11-19 S-trityl-L-Cysteine
2799-07-7
 US $30.00-55.00 / mg 97.02% 10g TargetMol Chemicals Inc.
(+)-S-Trityl-L-cysteine 97% pictures 2021-07-02 (+)-S-Trityl-L-cysteine 97%
2799-07-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
S-Trityl-L-cysteine pictures 2019-07-06 S-Trityl-L-cysteine
2799-07-7
 US $1.00 / KG 1KG 99% 20kg Career Henan Chemical Co
S-TRITYL-L-CYSTEINE TRITYL-L-CYSTEINE S-TRITYL-L-CYSTEINE CRYSTALLINE (+)-S-TRITYL-L-CYSTEINE 97% L-Cysteine, -3,3-D2-S-Trityl (R)-2-Amino-3-(tritylthio)propionic acid (R)-S-Tritylcysteine S-Trityl-(R)-cycteine S-TRITYL-L-CYSTEINE extrapure (2R)-2-AMino-3-[(triphenylMethyl)thio]propanoic Acid S-Trityl-(R)-cysteine Tritylthioalanine S-Trityl-L-cysteine,97% (R)-2-AMino-3-tritylsulfanyl-propionic acid L-CYSTEINE, S-TRITYL 3-(tritylthio)-l-alanin 3-tritylthio-l-alanine s-(triphenylmethyl)-l-cystein L-Cys(Trt)-OH S-Trityl-L-cysteine≥ 98% (HPLC) CYSTEINE(TRT)-OH EG5 INHIBITOR II NSC 83265 S-(TRIPHENYLMETHYL)-L-CYSTEINE (+)-S-TRITYL-L-CYSTEINE L-Cysteine, S-(triphenylmethyl)- S-Trityl-L-cysteine USP/EP/BP H-Cys(Trt)-OH (Cys of Non Animal Origin) (2R)-2-ammonio-3-[(triphenylmethyl)thio]propanoate (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid Dimethyl 5-bromopyridine-2,3-dicarboxylate H-L-Cys(Trt)-OH S-Tritylcysteine H-CYS(TRT)-OH H-Cys(Trt)-OH (Cys of Animal Origin) S-Tritylcysteine,Kinesin,StritylLCysteine,Apoptosis,328542,inhibit,cell cycle arrest,Inhibitor,NSC 83265,antitumor activities,NSC-83265,ATPase activity,kinesin Eg5,NSC83265,S trityl L Cysteine Tritylthioalanine (H-Cys(Trt)-OH) Impurity IIa-2 (S-triphenylmethylL-cysteine) 2799-07-7 2799-7-7 279-07-7 2799-07-07 7/7/2799 2799/7/7 328542 C6H53CSCD2CHNH2COOH C6H53CSCH2CHNH2CO2H Specialty Synthesis Peptide Synthesis Cysteine/Cystine CARBOXYLIC ACID Amino Acid Derivatives Cell Cycle Regulation Amino Acid Derivatives Amino Acids & Derivatives Aromatics Chiral Reagents Enzyme substrates