Istaroxime
- CAS No.
- 203737-93-3
- Chemical Name:
- Istaroxime
- Synonyms
- CS-1089;PST2744;PST 2744;PST-2744;Debio0614;Debio 0614;Istaroxime;PST2744/PST-2744;Istaroxime(PST2744);PST2744; PST 2744; ISTAROXIME; DEBIO 0614; DEBIO0614
- CBNumber:
- CB71508601
- Molecular Formula:
- C21H32N2O3
- Molecular Weight:
- 360.5
- MDL Number:
- MOL File:
- 203737-93-3.mol
| Boiling point | 511.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in H2O |
| form | Powder |
| pka | 9.49±0.10(Predicted) |
| FDA UNII | W8I9H2TPPL |
Istaroxime price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3507 | Istaroxime | 203737-93-3 | 2mg | $227 | 2021-12-16 | Buy |
| ApexBio Technology | A3507 | Istaroxime | 203737-93-3 | 5mg | $340 | 2021-12-16 | Buy |
| ApexBio Technology | A3507 | Istaroxime | 203737-93-3 | 10mg | $520 | 2021-12-16 | Buy |
| ApexBio Technology | A3507 | Istaroxime | 203737-93-3 | 50mg | $1457 | 2021-12-16 | Buy |
| DC Chemicals | DC7151 | Istaroxime(PST2744) >98% | 203737-93-3 | 100mg | $800 | 2021-12-16 | Buy |
Istaroxime Chemical Properties,Uses,Production
Biological Activity
istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (na+/k+ atpase). istaroxime is an investigational drug originally patented and developed by the italian pharmaceutical company sigma-tau. istaroxime is now under development for treatment of acute decompensated heart failure by cvie therapeutics.
in vitro
pst2744 inhibited the na+/k+-atpase activity from dog kidney with an ic50 value of 0.43 ± 0.15 μm [1]. the transient inward current (i(ti)) induced by a ca(2+) transient in the presence of complete na(+)/k(+) pump blockade was inhibited (-43%) by pst2744 but not by digoxin [2].
in vivo
intravenous infusion of 0.2 mg/kg/min pst2744 in anesthetized guinea pigs exerted an immediate and long-lasting inotropic effect (ed(80) of 1.89 +/- 0.37 mg/kg) without causing lethal arrhythmias up to a cumulative dose of 18 mg/kg [1]. istaroxime intravenous infusion (0.11 mg/kg per min) significantly increased both indices of contraction and relaxation (fractional shortening, +18+/-3.7%; aortic flow rate, +19+/-2.9%; peak myocardial systolic velocity, +36+/-7%; circumferential fiber shortening, +24+/-4.1%; peak atrial flow velocity, +69+/-8.6%; isovolumic relaxation time, +19+/-6.9%; and peak myocardial early diastolic velocity, +42+/-12%) [3]. in 5 animals, pst-2744 effects were compared with dobutamine. heart rates, pr intervals and qt intervals were unchanged following pst-2744 administration. pst-2744 increased contractility (+dp/dt) by 56% from 1881 +/- 282 mm hg/s to 2939 +/- 734 mm hg/s (p < 0.01) [4].
IC 50
0.43 ± 0.15 μm (na+/k+-atpase activity from dog kidney) [1]
Istaroxime Preparation Products And Raw materials
Raw materials
Preparation Products
Istaroxime Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32002 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9315 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19863 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
View Lastest Price from Istaroxime manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Istaroxime
203737-93-3
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2021-07-13 | Istaroxime
203737-93-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Istaroxime
203737-93-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Istaroxime
203737-93-3
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.
-
- Istaroxime
203737-93-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Istaroxime
203737-93-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd