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ChemicalBook >> CAS DataBase List >>N'-Nitro-L-arginine-methyl ester hydrochloride

N'-Nitro-L-arginine-methyl ester hydrochloride

CAS No.
51298-62-5
Chemical Name:
N'-Nitro-L-arginine-methyl ester hydrochloride
Synonyms
L-NAME;L-NAME HCL;H-Ala(No2)-Omecl;H-Ala(NO2)-OMeHCl;H-Arg(NO2)-OMe¤HC;H-Arg(NOZ)-OMe.HCl;H-ARG(NO2)-OME HCL;L-Arg(NO2)-Ome·HCl;H-Aeg(NO2)-OMe.HCL;H-L-Arg(NO2)-OMe*HCl
CBNumber:
CB6350079
Molecular Formula:
C7H16ClN5O4
Molecular Weight:
269.69
MDL Number:
MFCD00039052
MOL File:
51298-62-5.mol
MSDS File:
SDS
Last updated:2024-11-02 19:02:54

N'-Nitro-L-arginine-methyl ester hydrochloride Properties

Melting point 157-161 °C (dec.)
alpha 14.5 º (c=3, CH3OH)
RTECS RM2982570
refractive index 15 ° (C=3, MeOH)
storage temp. -20°C
solubility H2O: 50 mg/mL
form powder
color white to off-white
Water Solubility almost transparency
BRN 3744166
InChIKey QBNXAGZYLSRPJK-JEDNCBNOSA-N
CAS DataBase Reference 51298-62-5(CAS DataBase Reference)
FDA UNII TFX6A1PRZ1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
HS Code  29299090
NFPA 704
1
1 0

N'-Nitro-L-arginine-methyl ester hydrochloride price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N5751 Nω-Nitro-L-arginine methyl ester hydrochloride ≥98% (TLC), powder 51298-62-5 1g $53.6 2024-03-01 Buy
Sigma-Aldrich 483125-M NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem 51298-62-5 100mg $68.4 2024-03-01 Buy
TCI Chemical N0661 Nomega-Nitro-L-arginine Methyl Ester Hydrochloride >98.0%(HPLC)(T) 51298-62-5 5g $85 2024-03-01 Buy
TCI Chemical N0661 Nomega-Nitro-L-arginine Methyl Ester Hydrochloride >98.0%(HPLC)(T) 51298-62-5 25g $227 2024-03-01 Buy
Alfa Aesar H63666 Nomega-Nitro-L-arginine methyl ester hydrochloride, 98% 51298-62-5 5g $105 2024-03-01 Buy
Product number Packaging Price Buy
N5751 1g $53.6 Buy
483125-M 100mg $68.4 Buy
N0661 5g $85 Buy
N0661 25g $227 Buy
H63666 5g $105 Buy

N'-Nitro-L-arginine-methyl ester hydrochloride Chemical Properties,Uses,Production

Description

L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits Ki values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported Ki value for the inhibition of iNOS ranges from 4-65 μM. L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC50 of 0.54 μM.

Chemical Properties

Crystalline

Uses

Nitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.

Definition

ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.

General Description

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).

Biological Activity

NO synthase inhibitor.

Biochem/physiol Actions

Primary TargeteNOS

storage

Room temperature

N'-Nitro-L-arginine-methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 318)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18644 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21638 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58

View Lastest Price from N'-Nitro-L-arginine-methyl ester hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-NAME hydrochloride pictures 2024-11-04 L-NAME hydrochloride
51298-62-5
 US $46.00-76.00 / mg ≥98% 10g TargetMol Chemicals Inc.
N'-Nitro-L-arginine-methyl ester hydrochloride pictures 2024-11-04 N'-Nitro-L-arginine-methyl ester hydrochloride
51298-62-5
 US $0.00 / g/Bag 1g 98%min 1000g WUHAN FORTUNA CHEMICAL CO., LTD
N'-Nitro-L-arginine-methyl ester hydrochloride pictures 2024-04-17 N'-Nitro-L-arginine-methyl ester hydrochloride
51298-62-5
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd

N'-Nitro-L-arginine-methyl ester hydrochloride Spectrum

H-L-Arg(NO2)-OMe*HCl H-Arg(NOZ)-OMe.HCl methyl N5-[imino(nitroamino)methyl]-L-ornithine monohydrochloride H-Ala(NO2)-OMeHCl H-Ala(No2)-Omecl ω-Nitro-L-arginine methyl·hydrochloric acid NG-Nitro-L-arginine-methyl ester hydrochloride,98% Nω-Nitro-L-arginine methyl ester hydrochloride ,98% Nω-Nitro-L-arginine methyl ester hydrochloride,L-NAME hydrochloride L-Ornithine, N5-[iMino(nitroaMino)Methyl]-, Methyl ester, Monohydrochloride H-Arg(NO2)-OMe·HCl N-ω-Nitro-L-arginine Methyl ester hydrochloride NG-Nitro-L-arginine-Methyl ester hydrochloride, 98% 5GR N(gamma)-nitro-L-arginine methyl ester hydrochloride H-Arg(NO2)-OMe¤HC L-NAME hydrochloride H-Arg(NO2)-OMe·HCl L-NAME HCL L-NAME HYDROCHLORIDE L-NG-NITROARGININE METHYL ESTER HCL L-NG-NITROARGININE METHYL ESTER HYDROCHLORIDE H-ARG(NO2)-OME HCL H-ARG(NO2)-OME HYDROCHLORIDE ARGININE(NO2)-OME HCL H-Arg(NO2)-OMe·HCl S(+)-N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE METHYL ESTER HYDROCHLORIDE N-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE N-OMEGA-NO2-L-ARG-OME, HCL N-OMEGA-NO2-L-ARG-OME, HYDROCHLORIDE N-OMEGA-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE NG-NO2-L-ARG-OME, HCL NG-NO2-L-ARG-OME, HYDROCHLORIDE NG-NITRO-L-ARGININE-METHYL ESTER HCL NG-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE N(G)-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE, METHYL ESTER, MONOHYDROCHLORIDE L-NAME L-NG-Nitroarginine Methyl Ester (L-NAME) Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) L-Arg(NO2)-Ome·HCl H-Aeg(NO2)-OMe.HCL (S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride NG-nitro-L-Arg-OMe*HCl L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1) N5-NITRO-L-ARGININE METHYL ESTER DIHYDROCHLORIDE Nitro-L-arginineMethylEsterHCl NW-NITRO-L-ARGININEMETHYLESTERHYDROCHLORIDE H-Ala(NO2)-OMe hydrochloride NITROARGININEMETHYLESTERHYDROCHLORIDE Nω-Nitro-L-Arginine Methyl ester hydrochloride, 98%, a nonselective inhibitor of nitric oxide synthetases (NOS) NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride) NG-Nitroarginine methyl ester hydrochloride methyl (2S)-2-amino-5-(N'-nitrocarbamimidamido)pentanoate hydrochloride Nω-Nitro-L-arginineMethylEsterHydrochloride> N'-Nitro-L-arginine-methyl ester hydrochloride USP/EP/BP 2-(4-amino-5-oxohexyl)-1-nitroguanidine hydrochloride Nω-Nitro-L-arginine methyl ester hydrochloride Argatroban Impurity 75 HCl