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ChemicalBook >> CAS DataBase List >>Methylergonovine maleate salt

Methylergonovine maleate salt

CAS No.
57432-61-8
Chemical Name:
Methylergonovine maleate salt
Synonyms
Erezin;Derganin;Partan M;erezingen;Metenarin;Methergin;methergine;Ryegonovin;Basofortina;Spametrin F
CBNumber:
CB6343310
Molecular Formula:
C24H29N3O6
Molecular Weight:
455.51
MDL Number:
MFCD00078588
MOL File:
57432-61-8.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:14

Methylergonovine maleate salt Properties

Melting point 1720C (dec)
Boiling point 561.98°C (rough estimate)
Density 1.2744 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. -20°C Freezer
solubility H2O: 25 mg/mL
form Solid
color white
Water Solubility Soluble to 25 mM in water
FDA UNII IR84JPZ1RK

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301+H311+H331-H361
Precautionary statements  P201-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Hazard Codes  T
Risk Statements  23/24/25-62
Safety Statements  36/37/39-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  KE5500000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2939690000

Methylergonovine maleate salt price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1430000 Methylergonovine maleate United States Pharmacopeia (USP) Reference Standard 57432-61-8 50mg $261.6 2024-03-01 Buy
Tocris 0549 Methylergometrinemaleate ≥98%(HPLC) 57432-61-8 250 $473 2021-12-16 Buy
Tocris 0549 Methylergometrinemaleate ≥98%(HPLC) 57432-61-8 50 $116 2021-12-16 Buy
Usbiological 255800 Methylergometrine maleate 57432-61-8 50mg $366 2021-12-16 Buy
Usbiological 016814 Methyl Ergonovine Maleate Salt 57432-61-8 5mg $460 2021-12-16 Buy
Product number Packaging Price Buy
1430000 50mg $261.6 Buy
0549 250 $473 Buy
0549 50 $116 Buy
255800 50mg $366 Buy
016814 5mg $460 Buy

Methylergonovine maleate salt Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Methergine,Sandoz,US,1948

Uses

A metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic

Definition

ChEBI: Methylergonovine Maleate is an ergoline alkaloid. It has a role as a geroprotector.

Manufacturing Process

To a freshly prepared solution of 2 parts of d-isolysergic acid azide in 300 parts of either is added an ethereal solution of 2 parts of d-2-aminobutanol-1 and the mixture is left to stand at room temperature during 12 hours. The yellowish clear solution is then washed several times with some water, dried over sodium sulfate and the ether evaporated in vacuo. The crystallized residue is treated with a small quantity of acetone and filtered. Yield: 2.2 parts of d-isolysergic acid-d-1-hydroxybutylamide-2. On recrystallization from some hot methanol the new compound is obtained in form of beautiful polygonal crystals that melt with some decomposition at 192° to 194°C (corr.).
1 part of the iso-compound is then dissolved in 10 parts of absolute ethanol and an alcoholic potassium hydroxide solution is added thereto. The mixture is left to stand at room temperature during 45 minutes. After this time equilibrium is reached between lysergic acid and the isolysergic acid forms, which can be checked by determination of the constancy of the optical rotation of the solution. When this point is reached, potassium hydroxide is transformed into potassium carbonate by bubbling through the solution a stream of carbon dioxide; the thick crystal paste of potassium carbonate is then diluted with 50 parts of ether, filtered and washed again with 50 parts of ether.
The alcoholic ethereal filtrate is then dried over calcined potassium carbonate and the solution evaporated, whereby 0.9 to 1 part of a mixture of d-lysergic acid-d-1-hydroxybutylamide-2 and of d-isolysergic acid-d-1- hydroxybutylamide-2 is obtained. In order to separate the isomers, the residue is dissolved in 15 parts of hot chloroform and filtered from the small quantity of inorganic salt, whereby on cooling down, the difficultly soluble chloroform compound of d-lysergic acid-d-1-hydroxybutylamide-2 crystallizes out. Yield: 0.4 part. This compound can be recrystallized from hot benzene, whereby crystals melting with some decomposition at 172°C (corr.) are obtained. It may then be reacted with maleic acid to give the maleate.

brand name

Methergine(Novartis).

Therapeutic Function

Oxytocic

storage

Desiccate at RT

Methylergonovine maleate salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 86)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5858 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32070 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
henan kanbei chemical co.,ltd 		+undefined-86-1523780-4566 +undefined15237804566 henankanbeichemical@163.com China 511 58
Wuhan senwayer century chemical Co.,Ltd 		+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 902 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20288 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58

View Lastest Price from Methylergonovine maleate salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methylergonovine maleate salt pictures 2024-10-25 Methylergonovine maleate salt
57432-61-8
 US $0.00-0.00 / kg 1kg 99% 6000 kg Hebei Yanxi Chemical Co., Ltd.
Methylergonovine maleate salt pictures 2024-09-25 Methylergonovine maleate salt
57432-61-8
 US $220.00 / KG 0.10000000149011612KG 99% min 20 TONS Wuhan Senwayer Century Chemical Co.,Ltd
Methylergonovine maleate salt pictures 2024-04-17 Methylergonovine maleate salt
57432-61-8
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
erezingen maleicacid,methylergonovine METHYLERGOMETRINE MALEATE METHYLERGONOVINE MALEATE METHYLERGONOVINE MALEATE SALT METHYLERGONOVINE MALEIC ACID SALT 9,10-DIDEHYDRO-N-[(S)-1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8BETA-CARBOXAMIDE MALEATE SALT [8B(S)]-9,10-DIDEHYDRO-N-[1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8-CARBOXAMIDE MALEATE methergine methylergobasinemaleate methyl-ergonovinmaleate(1:1) (8b)-9,10-Didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-ergoline-8-carbox-amide Maleate Basofortina Erezin Metenarin Methergin Methylergobasine Maleat N-[a-(Hydroxymethyl)propyl]-D-lysergamide Maleate 9,10-didehydro-n-[(s)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide maleate salt Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-, (8b)-, (2Z)-2-butenedioate (1:1) (salt) (9CI) Ergonovine, methyl-, compd. with maleic acid (6CI) Ryegonovin Spametrin F (8)-9,10-Didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-6-methyl-ergoline-8-carbox-amide Maleate Methergine maleate salt, 9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-6-methylergoline-8β-carboxamide maleate salt Derganin Partan M Einecs 260-734-4 Ergoline-8-carboxamide, 9,10-didehydro-N-((1S)-1-(hydroxymethyl)propyl)-6-methyl-, (8beta)-, (2Z)-2-butenedioate (1:1) (salt) Ergoline-8-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-6-methyl-, (8beta(S))-, (Z)-2-butenedioate (1:1) (salt) Ergonovine, methyl-, maleate (1:1) Methylergonovine Maleate (50 mg) (List Chemical) N-[α-(HydroxyMethyl)propyl]-D-lysergaMide Maleate Methergine maleate salt Methylergometrine for system suitability -* Drug Precursor -*narc CRS Methylergometrine maleate CRS (6aR,9R)-N-[(1S)-1-(Hydroxymethyl)propyl]-7-methyl- 4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (Z)-butenedioate Methylergonovine maleate salt USP/EP/BP Methylergonovine MaleateQ: What is Methylergonovine Maleate Q: What is the CAS Number of Methylergonovine Maleate Q: What is the storage condition of Methylergonovine Maleate Q: What are the applications of Methylergonovine Maleate Methylergonovine Maleate (1430000) Methylergonovine Maleate，Methylergonovine maleate salt (6aR,9R)-N-((R)-1-hydroxybutan-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide maleate 57432-61-8 C20H25N3O2C4H4O4 METHERGINE Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals