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ChemicalBook >> CAS DataBase List >>ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]-

ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]-

CAS No.
1049722-30-6
Chemical Name:
ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]-
Synonyms
Targapremir-210;Targapremir-210 (TGP-210);Targapremir 210,Targapremir210;ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]-;N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanamide;N-(3-azidopropyl)-4-[3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenoxy]butanamide
CBNumber:
CB62716156
Molecular Formula:
C32H36N10O2
Molecular Weight:
592.71
MDL Number:
MFCD28386319
MOL File:
1049722-30-6.mol
Last updated:2024-07-02 08:55:13

ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- Properties

storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (421.81 mM)
form Solid
color Light yellow to yellow

ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 6586 Targapremir210 ≥98%(HPLC) 1049722-30-6 5 $265 2021-12-16 Buy
ChemScene CS-0009412 Targapremir-210 98.02% 1049722-30-6 10mg $460 2021-12-16 Buy
ChemScene CS-0009412 Targapremir-210 98.02% 1049722-30-6 25mg $920 2021-12-16 Buy
ChemScene CS-0009412 Targapremir-210 98.02% 1049722-30-6 50mg $1650 2021-12-16 Buy
ChemScene CS-0009412 Targapremir-210 98.02% 1049722-30-6 100mg $2800 2021-12-16 Buy
Product number Packaging Price Buy
6586 5 $265 Buy
CS-0009412 10mg $460 Buy
CS-0009412 25mg $920 Buy
CS-0009412 50mg $1650 Buy
CS-0009412 100mg $2800 Buy

ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- Chemical Properties,Uses,Production

Biological Activity

Targapremir-210 (TGP-210) is a potent and selective miR-210 inhibitor. It can inhibits pre-miR-210 processing with high affinity (Kd~200 nM).

in vitro

Targapremir-210 decreases mature miR-210 levels in MDA-MB-231 cells cultured under hypoxic conditions, with an IC 50 of～200 nM.
It (200 nM) induces apoptosis in MDA-MB-231 cells is selective for the hypoxic environment. Targapremir-210 induces apoptosis in cells under hypoxic conditions and does not induce apoptosis in MDA-MB-231 cells cultured in normoxia.

in vivo

Targapremir-210 (100 μL of 200 nM; single ip injection) impedes MDA-MB-231 triple negative breast cancer (TNBC) cells proliferation in vivo. It is able to reach the tumor and sustain for the entire 21-day period, and decreases tumor burden in a TNBC mouse model.

target

IC50: 200 nM (miR-210, in MDA-MB-231 cells).

storage

Store at -20°C

ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32079 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12306 58
Chongqing Chemieliva Pharmaceutical Co., Ltd. 023-67770219 jessica.hu@chemieliva.com China 1443 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2358 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- N-(3-azidopropyl)-4-[3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenoxy]butanamide Targapremir-210 N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanamide Targapremir-210 (TGP-210) Targapremir 210,Targapremir210 1049722-30-6