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ChemicalBook >> CAS DataBase List >>MeriMepodib, VI-21497, VX-497

MeriMepodib, VI-21497, VX-497

CAS No.
198821-22-6
Chemical Name:
MeriMepodib, VI-21497, VX-497
Synonyms
VI 21497;MeriMepodib, VI-21497, VX-497;MERIMEPODIB; VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497;(S)-Tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate;HCV,Inhibitor,Merimepodib,HBV,Hepatitis C virus,Hepatitis B virus,VX497,VX 497,inhibit,MMPD;[(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate;[[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]carbamic acid (3S)-tetrahydro-3-furanyl ester;Carbamic acid, N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-, (3S)-tetrahydro-3-furanyl ester
CBNumber:
CB62680808
Molecular Formula:
C23H24N4O6
Molecular Weight:
452.46
MDL Number:
MFCD09837807
MOL File:
198821-22-6.mol
Last updated:2024-11-07 21:39:59

MeriMepodib, VI-21497, VX-497 Properties

Boiling point 571.4±50.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility ≥45.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 11.66±0.46(Predicted)
color Off-white to light yellow
FDA UNII 2ZL2BA06FU

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
NFPA 704
0
2 0

MeriMepodib, VI-21497, VX-497 price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29351 Merimepodib 198821-22-6 1mg $32 2024-03-01 Buy
Cayman Chemical 29351 Merimepodib 198821-22-6 25mg $533 2024-03-01 Buy
Cayman Chemical 29351 Merimepodib 198821-22-6 5mg $139 2024-03-01 Buy
Cayman Chemical 29351 Merimepodib 198821-22-6 10mg $243 2024-03-01 Buy
ApexBio Technology B1112 Merimepodib 198821-22-6 5mg $326 2021-12-16 Buy
Product number Packaging Price Buy
29351 1mg $32 Buy
29351 25mg $533 Buy
29351 5mg $139 Buy
29351 10mg $243 Buy
B1112 5mg $326 Buy

MeriMepodib, VI-21497, VX-497 Chemical Properties,Uses,Production

Description

Merimepodib is an inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Kis = 7 and 10 nM for IMPDH type I and type II, respectively) with antiviral and immunosuppressant activities. It reduces Ebola, Lassa, chikungunya, Junin, and Zika virus titers in vitro and inhibits Zika virus replication in Huh7 cells (EC50 = 0.6 μM). Merimepodib inhibits the proliferation of PHA-stimulated T cells and SPAS-stimulated B cells (IC50s = 104 and 132 nM, respectively), effects that can be reversed by guanosine but not adenosine . In vivo, merimepodib (50 and 100 mg/kg) increases allograft survival in a murine skin transplantation model and prevents development of graft versus host disease (GVHD) in splenocyte allografted mice.

Uses

Inhibition of inosine monophosphate dehydrogenase (IMPDH), which has potential antiviral, antiproliferative, antiparasitic, and immunosuppressive activity.

in vitro

vx-497 (mw 452.5) inhibited the proliferation of primary human, rat, mouse, and dog lymphocytes at concentrations of approximately 100 nm. the inhibitory effect of vx-497 on lymphocytes was reversed in the presence of exogenous guanosine, but not in the presence of adenosine or uridine, confirming that the antilymphocytic activity of vx-497 was specifically due to inhibition of impdh[1]. vx-497 was most potent against the first group of viruses on virus replication, which included hbv, hcmv, emcv, and rsv, with ic50 values of 0.38, 0.80, 1.0, and 1.14 μm, respectively [3].

in vivo

oral administration of vx-497 dose-dependently inhibited the primary igm antibody response, with an ed50 value of approximately 30-35 mg/kg in mice. single daily dosing of vx-497 was as effective as twice-daily dosing in this model of immune activation [1].in the skin transplant study, trunk skin grafts from balb/c mice were grafted onto c57bl/6 mice. administration of vx-497 twice daily until day 10 significantly prolonged graft survival to 13.2 ± 1.2 (p < 0.001, kaplan meier log-rank test) days in the 50 mg/kg group and 13.9 ± 1.0 (p < 0.001) days in the 85 mg/kg group [4].

References

[1]. jain j1, almquist sj,shlyakhter d,harding mw. vx-497: a novel, selective impdh inhibitor and immunosuppressive agent.j pharm sci.2001 may;90(5):625-37.
[2]. pimkin m1,markham gd. inosine 5'-monophosphate dehydrogenase.adv enzymol relat areas mol biol.2009;76:1-53.
[3]. markland w1,mcquaid tj,jain j,kwong ad. broad-spectrum antiviral activity of the imp dehydrogenase inhibitor vx-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon.antimicrob agents chemother.2000 apr;44(4):859-66.
[4]. decker cj1,heiser ad,chaturvedi pr,faust tj,ku g,moseley s,nimmesgern e. the novel impdh inhibitor vx-497 prolongs skin graft survival and improves graft versus host disease in mice.drugs exp clin res.2001;27(3):89-95.

MeriMepodib, VI-21497, VX-497 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29814 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9315 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38465 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33338 58

View Lastest Price from MeriMepodib, VI-21497, VX-497 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Merimepodib pictures 2024-11-08 Merimepodib
198821-22-6
 US $39.00-163.00 / mg 99.66% 10g TargetMol Chemicals Inc.
Merimepodib pictures 2021-07-13 Merimepodib
198821-22-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Merimepodib pictures 2021-07-09 Merimepodib
198821-22-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Merimepodib pictures
  • Merimepodib
    198821-22-6
  • US $39.00-163.00 / mg
  • 99.66%
  • TargetMol Chemicals Inc.
  • Merimepodib pictures
  • Merimepodib
    198821-22-6
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Merimepodib pictures
  • Merimepodib
    198821-22-6
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
MeriMepodib, VI-21497, VX-497 [[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]carbamic acid (3S)-tetrahydro-3-furanyl ester VI 21497 Carbamic acid, N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-, (3S)-tetrahydro-3-furanyl ester [(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate MERIMEPODIB; VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497 (S)-Tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate HCV,Inhibitor,Merimepodib,HBV,Hepatitis C virus,Hepatitis B virus,VX497,VX 497,inhibit,MMPD 198821-22-6