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ChemicalBook >> CAS DataBase List >>Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-

CAS No.
2451481-08-4
Chemical Name:
Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-
Synonyms
sulfopin;1-dioxido-3-thienyl)-;2-dimethylpropyl)-N-(tetrahydro-1;2-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide;Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-;neuroblastoma,antiproliferative,PIN1-3,tumors,cancer,pancreatic,Inhibitor,sulfopin,inhibit,cells,HEK293
CBNumber:
CB58215081
Molecular Formula:
C11H20ClNO3S
Molecular Weight:
281.8
MDL Number:
MFCD32860123
MOL File:
2451481-08-4.mol
Last updated:2024-11-18 17:01:59

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Properties

Boiling point 455.5±45.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
pka -1.36±0.20(Predicted)
color Off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05
Signal word  Danger
Hazard statements  H318-H335-H315
Precautionary statements  P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
DC Chemicals 028490 Sulfopin 2451481-08-4 001 $350 2021-12-16 Buy
Product number Packaging Price Buy
028490 001 $350 Buy

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Chemical Properties,Uses,Production

Description

Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although it displayed little to no cytotoxicity against a panel of 300 cancer cell lines, it had a significant impact on cancer cell growth after prolonged treatment. It suppressed MYCN-driven neuroblastoma initiation and the growth and survival of primary neuroblastoma tumor cell transplants in zebrafish.

References

Dubiella et al. (2021), Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo; Nat. Cham. Biol. 17 954

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32112 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38596 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 968 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8011 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2995 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613 sales@chemrenpharm.com China 3600 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 yutianchun2007@126.com China 10002 58

View Lastest Price from Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
sulfopin pictures 2024-11-18 sulfopin
2451481-08-4
 US $33.00-76.00 / mg 99.99% 10g TargetMol Chemicals Inc.
  • sulfopin pictures
  • sulfopin
    2451481-08-4
  • US $33.00-76.00 / mg
  • 99.99%
  • TargetMol Chemicals Inc.

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Spectrum

2451481-08-4(Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-)Related Search:

Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- sulfopin 1-dioxido-3-thienyl)- 2-dimethylpropyl)-N-(tetrahydro-1 neuroblastoma,antiproliferative,PIN1-3,tumors,cancer,pancreatic,Inhibitor,sulfopin,inhibit,cells,HEK293 2-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide 2451481-08-4 C11H20ClNO3S