ChemicalBook >> CAS DataBase List >>2-Methylpropanedioic acid
2-Methylpropanedioic acid
- CAS No.
- 516-05-2
- Chemical Name:
- 2-Methylpropanedioic acid
- Synonyms
- METHYLMALONIC ACID;2-Methylmalonic acid;AI315327;NSC 25201;onic acid;AI3 15327;AI3-15327;Methylmalonic;isosuccinicacid;Isosuccinic acid
- CBNumber:
- CB5713714
- Molecular Formula:
- C4H6O4
- Molecular Weight:
- 118.09
- MDL Number:
- MFCD00002656
- MOL File:
- 516-05-2.mol
- MSDS File:
- SDS
Last updated:2025-02-14 15:59:18
| Melting point | 128-130 °C (lit.) |
|---|---|
| Boiling point | 272.71°C (rough estimate) |
| Density | 1.45 |
| refractive index | 1.4304 (estimate) |
| Flash point | 2℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 3.07, 5.76(at 25℃) |
| color | White |
| Specific Gravity | 1.455 |
| PH | 3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution) |
| Water Solubility | soluble |
| BRN | 1756084 |
| CAS DataBase Reference | 516-05-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 8LL8S712J7 |
| NIST Chemistry Reference | Methylmalonic acid(516-05-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn,F | |||||||||
| Risk Statements | 36/37/38-36-20/21/22-11 | |||||||||
| Safety Statements | 26-36/37-16 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OO1400000 | |||||||||
| HS Code | 29171900 | |||||||||
| NFPA 704 |
|
2-Methylpropanedioic acid price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M54058 | Methylmalonic acid 99% | 516-05-2 | 5g | $65.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | M-080 | Methylmalonic acid solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 516-05-2 | 1mL | $113 | 2024-03-01 | Buy |
| TCI Chemical | M0568 | Methylmalonic Acid >98.0%(T) | 516-05-2 | 25g | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 14885 | Methylmalonate ≥95% | 516-05-2 | 1g | $20 | 2024-03-01 | Buy |
| Cayman Chemical | 14885 | Methylmalonate ≥95% | 516-05-2 | 5g | $48 | 2024-03-01 | Buy |
2-Methylpropanedioic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Methylmalonic acid can be used as a substrate in:
- Esterification reactions by various catalysts.
- Synthesis of pyrimidinium betaines with formamidine.
- Synthesis of malonic acid half thioester (MAHT).
Uses
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
Definition
ChEBI: Methylmalonic acid is a dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. It has a role as a human metabolite. It is functionally related to a malonic acid. It is a conjugate acid of a methylmalonate(1-).
Biological Functions
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
General Description
Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
storage
Store at RT
Purification Methods
The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]
2-Methylpropanedioic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 310)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen Yunfan Biotech Co.,Ltd. | +8618050056030 | yezhaobao@yfpharm.com | China | 27 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8803 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12825 | 58 |
| Hubei Yiling biotechnology Co Ltd | +86-18163349544 +86-18163349544 | mollylucking@foxmail.com | China | 2709 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 19875 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29869 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 18568 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 2-Methylpropanedioic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-28 | 2-Methylpropanedioic acid
516-05-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-02-19 | 2-Methylpropanedioic acid
516-05-2
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2025-02-15 | 2-Methylpropanedioic acid
516-05-2
|
US $0.00 / G/KG | 1G/KG | 99% | 100MT | Hubei Yiling biotechnology Co Ltd |
-
- 2-Methylpropanedioic acid
516-05-2
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2-Methylpropanedioic acid
516-05-2
- US $1.00 / kg
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- 2-Methylpropanedioic acid
516-05-2
- US $0.00 / G/KG
- 99%
- Hubei Yiling biotechnology Co Ltd
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516-05-2 2-Methylpropanedioic acid C4H6O4
AI3 15327
AI315327
AI3-15327
METHYLMALONIC ACID
2-Methylmalonic acid
NSC 25201|||MMA|||Isosuccinic acid|||Methylpropanedioic acid|||Methylmalonate
Methylmalonic acid in methanol
Methylmalonic Acid in Acetonitrile
Methyl Malonic Acid / 2-Methylpropanedioc acid
Methylmalonic acid, 10 mM in DMSO
516-05-2
HOOCCHCH3COOH
CH3CHCO2H2
Carboxylic Acids
Carbonyl Compounds
C1 to C5
Building Blocks
Organic Building Blocks
Building Blocks
C1 to C5
Carbonyl Compounds
Carboxylic Acids
Chemical Synthesis
Organic Building Blocks
Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
API intermediates
Aliphatics
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals