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ChemicalBook >> CAS DataBase List >>ZT-12-037-01

ZT-12-037-01

CAS No.
2328073-61-4
Chemical Name:
ZT-12-037-01
Synonyms
ZT-12-037-01;inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor;N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
CBNumber:
CB54927142
Molecular Formula:
C21H31N5O2
Molecular Weight:
385.5
MDL Number:
MFCD32197197
MOL File:
2328073-61-4.mol
Last updated:2024-11-19 15:53:33

ZT-12-037-01 Properties

storage temp. 2-8°C(protect from light)
solubility DMSO: 8.33 mg/mL (21.61 mM)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

ZT-12-037-01 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0090099 ZT-12-037-01 98.21% 2328073-61-4 5mg $80 2021-12-16 Buy
ChemScene CS-0090099 ZT-12-037-01 98.21% 2328073-61-4 10mg $140 2021-12-16 Buy
Axon Medchem Axon2937 ZT-12-037-01 99% 2328073-61-4 25mg $335.5 2021-12-16 Buy
ChemScene CS-0090099 ZT-12-037-01 98.21% 2328073-61-4 50mg $560 2021-12-16 Buy
ChemScene CS-0090099 ZT-12-037-01 98.21% 2328073-61-4 100mg $980 2021-12-16 Buy
Product number Packaging Price Buy
CS-0090099 5mg $80 Buy
CS-0090099 10mg $140 Buy
Axon2937 25mg $335.5 Buy
CS-0090099 50mg $560 Buy
CS-0090099 100mg $980 Buy

ZT-12-037-01 Chemical Properties,Uses,Production

Biological Activity

ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.

in vitro

Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.

in vivo

ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.

target

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ZT-12-037-01 Preparation Products And Raw materials

Raw materials

Preparation Products

ZT-12-037-01 Suppliers

Global( 41)Suppliers
TargetValue
STK19
(Cell-free assay)		 23.96 nM
STK19 (D89N)
(Cell-free assay)		 27.94 nM
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32112 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38596 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 1009 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8011 62

View Lastest Price from ZT-12-037-01 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZT-12-037-01 pictures 2024-11-19 ZT-12-037-01
2328073-61-4
 US $30.00-117.00 / mg 99.56% 10g TargetMol Chemicals Inc.
  • ZT-12-037-01 pictures
  • ZT-12-037-01
    2328073-61-4
  • US $30.00-117.00 / mg
  • 99.56%
  • TargetMol Chemicals Inc.

ZT-12-037-01 Spectrum

2328073-61-4(ZT-12-037-01)Related Search:

ZT-12-037-01 2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]- inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine 2328073-61-4