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ChemicalBook >> CAS DataBase List >>UMI-77

UMI-77

CAS No.
518303-20-3
Chemical Name:
UMI-77
Synonyms
UMI-77;CS-1799;UMI 77;UMI77;UMI-77 USP/EP/BP;UMI-77, 10 mM in DMSO;Bcl-2 Family,UMI-77,Inhibitor,inhibit;2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid;2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid;Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-;2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77
CBNumber:
CB52729658
Molecular Formula:
C18H14BrNO5S2
Molecular Weight:
468.34
MDL Number:
MFCD03471890
MOL File:
518303-20-3.mol
Last updated:2025-01-27 09:38:02

UMI-77 Properties

Boiling point 661.2±65.0 °C(Predicted)
Density 1.79±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥23.4 mg/mL in DMSO; insoluble in H2O; ≥7.2 mg/mL in EtOH
form solid
pka 2.41±0.30(Predicted)
color White to off-white
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

UMI-77 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19148 UMI-77 ≥98% 518303-20-3 1mg $32 2024-03-01 Buy
Cayman Chemical 19148 UMI-77 ≥98% 518303-20-3 5mg $93 2024-03-01 Buy
Cayman Chemical 19148 UMI-77 ≥98% 518303-20-3 10mg $169 2024-03-01 Buy
Usbiological 468454 UMI-77 518303-20-3 1mg $382 2021-12-16 Buy
TRC U700850 UMI-77 518303-20-3 1mg $100 2021-12-16 Buy
Product number Packaging Price Buy
19148 1mg $32 Buy
19148 5mg $93 Buy
19148 10mg $169 Buy
468454 1mg $382 Buy
U700850 1mg $100 Buy

UMI-77 Chemical Properties,Uses,Production

Uses

UMI-77 acts as a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Anticancer agent.

Biological Activity

umi-77 is a novel small-molecule inhibitor of mcl-1 with ki and ic50 values of 0.49 μm and 0.31 μm [1].myeloid cell leukemia-1 (mcl-1) is a member of the prosurvival bcl-2 family and is a potent anti-apoptotic protein. mcl-1 acts as an important survival factor in a broad range of human cancers [1].umi-77 is a novel small-molecule mcl-1 inhibitor. in fp-based binding assays, umi-77 potently and selectively displaced fluorescent labeled bid-bh3 peptide from mcl-1 protein with ki value of 0.49μm and bound to the bh3 binding pocket of mcl-1 protein. umi-77 bound to a1/bfl-1, bcl-w, bcl-2 and bcl-xl with ki values of 5.33, 8.19, 23.83 and 32.99μm. in a pull-down assay, umi-77 at 10 μm effectively and dose-dependently inhibited the interactions between bl-noxa and cellular mcl-1. it was reported that mcl-1 regulates pro-apoptotic bax and bak proteins and preventing their pro-apoptotic activity. umi-77 dose-dependently inhibited the binding of mcl-1 to bax with ic50 value of 1.43μm. in pc cells, umi-77 inhibited cell growth and induced apoptosis in a time and dose-dependent way [1].in bxpc-3 xenografted scid mice model, umi-77 exhibited robust anti-tumor efficacy with no toxicity. also, umi-77 decreased the anti-apoptotic protein survivin, which potently inhibited apoptosis by antagonizing caspase activity [1].

References

[1]. abulwerdi f, liao c, liu m, azmi as, et al. a novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther, 2014, 13(3): 565-575.

UMI-77 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22787 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58

View Lastest Price from UMI-77 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
UMI-77 pictures 2024-11-17 UMI-77
518303-20-3
 US $36.00-122.00 / mg 99.57% 10g TargetMol Chemicals Inc.
Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?- pictures 2020-01-02 Acetic acid, 2-?[[4-?[[(4-?bromophenyl)?sulfonyl]?amino]?-?1-?hydroxy-?2-?naphthalenyl]?thio]?-
518303-20-3
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • UMI-77 pictures
  • UMI-77
    518303-20-3
  • US $36.00-122.00 / mg
  • 99.57%
  • TargetMol Chemicals Inc.

UMI-77 Spectrum

518303-20-3(UMI-77)Related Search:

2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid UMI-77 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid 2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77 Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- UMI 77;UMI77 CS-1799 UMI-77 USP/EP/BP Bcl-2 Family,UMI-77,Inhibitor,inhibit UMI-77, 10 mM in DMSO 518303-20-3 Inhibitors API