ChemicalBook >> CAS DataBase List >>PIK-75
PIK-75
- CAS No.
- 372196-67-3
- Chemical Name:
- PIK-75
- Synonyms
- CS-669;PIK 75;PIK75(HCl salt);PIK-75, free base;PIK-75 Hydrochloride;PI3-Kinase a Inhibitor VIII;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;(Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
- CBNumber:
- CB52484861
- Molecular Formula:
- C16H14BrN5O4S
- Molecular Weight:
- 452.28
- MDL Number:
- MFCD20526318
- MOL File:
- 372196-67-3.mol
- MSDS File:
- SDS
Last updated:2023-07-14 17:30:05
| Melting point | >203°C (dec.) |
|---|---|
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 2.08±0.50(Predicted) |
| color | Light Yellow to Yellow |
| FDA UNII | 9058I8S63D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P301+P312-P302+P352-P305+P351+P338 |
PIK-75 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 462617 | PIK-75 | 372196-67-3 | 1mg | $312 | 2021-12-16 | Buy |
| TRC | P437670 | PIK-75 | 372196-67-3 | 50mg | $340 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181090 | PIK-75 >98% | 372196-67-3 | 250mg | $912.9 | 2021-12-16 | Buy |
| Matrix Scientific | 132629 | (E)-N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide 97% | 372196-67-3 | 100mg | $1080 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1067-M005 | PIK-75 ≥95% | 372196-67-3 | 5mg | $70 | 2021-12-16 | Buy |
PIK-75 Chemical Properties,Uses,Production
Uses
PIK-75 is a p110α inhibitor, isoform-specific mutants at Ser773, and also potently inhibits DNA-PK.
Definition
ChEBI: N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide.
Enzyme inhibitor
This novel phosphoinositide-3 kinase p110α inhibitor (F.Wt. = 488.74; CAS 372196-67-3; Solubility (25°C): 98 mg/mL DMSO, <1 mg/mL Water), also known as (E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2- dimethyl-5-nitrobenzenesulfonohydrazide-HCl, competes with respect to a substrate (phosphatidylinositol, PI), unlike most other PI3K inhibitors, which bind at or near the ATP site. PIK-75 exhibits impressive isoform selectivity, with an IC50 value of 5.8 nM for p110α, while the corresponding IC50 values are 1300 nM, 76 nM and 510 nM for p110β, p110γ, and p110δ, respectively.
PIK-75 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 86)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32118 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6005 | 61 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2229 | 55 |
2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
PIK-75 Hydrochloride
Benzenesulfonic acid, 2-Methyl-5-nitro-, 2-[(6-broMoiMidazo[1,2-a]pyridin-3-yl)Methylene]-1-Methylhydrazide
PIK75(HCl salt)
PI3-Kinase a Inhibitor VIII
PIK 75
CS-669
PIK-75, free base
(Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
PIK-75,pancreatic,PKB,cells,apoptotic,p110α,inhibit,PI3K,Phosphoinositide 3-kinase,DNA-PK,PIK75,cancer,Inhibitor,CHO-IR,DNA-dependent protein kinase,Apoptosis,PIK 75
N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
372196-67-3
C16H14BrN5O4S
Inhibitors
Antineoplastic