成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> CAS DataBase List >>[2H3]- Vincristine Sulfate

[2H3]- Vincristine Sulfate

CAS No.
1217854-24-4
Chemical Name:
[2H3]- Vincristine Sulfate
Synonyms
[2H3]- Vincristine Sulfate;Vincristine-d3-ester (sulfate);Vincristine-d3 (Methyl ester-D3) Sulfate
CBNumber:
CB48009197
Molecular Formula:
C46H58N4O14S
Molecular Weight:
923.04
MDL Number:
MOL File:
1217854-24-4.mol
Last updated:2023-05-21 10:59:17

[2H3]- Vincristine Sulfate Properties

storage temp. Store at -20°C, protect from light, stored under nitrogen
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Pale Beige
Stability Hygroscopic

[2H3]- Vincristine Sulfate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC V314252 Vincristine-d3Sulfate 1217854-24-4 1mg $275 2021-12-16 Buy
Product number Packaging Price Buy
V314252 1mg $275 Buy

[2H3]- Vincristine Sulfate Chemical Properties,Uses,Production

Uses

Labelled Vincristine. An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.

Biological Activity

Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Jordan, M.A., et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res, 1985. 45(6): p. 2741-7. [3]. Gidding, C.E., et al, Vincristine revisited. Crit Rev Oncol Hematol, 1999. 29(3): p. 267-87. [4]. Donoso, J.A., et al, Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res, 1977. 37(5): p. 1401-7. [5]. Horton, J.K., et al. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol, 1988. 37(20): p. 3995-4000. [6]. Baguley, B.C., et al, Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer, 1991. 27(4): p. 482-7. [7]. Zhang D, et al. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. Int J Nanomedicine. 2017 Mar 16;12:2081-2108.

[2H3]- Vincristine Sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

[2H3]- Vincristine Sulfate Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44808 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 4997 58
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900 judy.xia@synzest.com China 12582 58
[2H3]- Vincristine Sulfate Vincristine-d3-ester (sulfate) Vincristine-d3 (Methyl ester-D3) Sulfate 1217854-24-4