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PG 931
- CAS No.
- 667430-81-1
- Chemical Name:
- PG 931
- Synonyms
- PG 931;Ac-Nle-cyclo（Asp-Pro-D-Phe-Arg-Trp-Lys)-Pro-Val-NH2;L-Valinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-prolyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysyl-L-prolyl-, (2→7)-lactam
- CBNumber:
- CB44727460
- Molecular Formula:
- C59H85N15O11
- Molecular Weight:
- 1180.42
- MDL Number:
- MOL File:
- 667430-81-1.mol
Last updated:2024-07-02 08:55:09
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PG 931 Chemical Properties,Uses,Production
Biological Activity
PG-931 is an analog of SHU 9119 (HY-P0227). PG-931 is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist, more selective than hMC3R (IC50=55 nM) or hMC5R (IC50=2.4 nM). It can reverse hemorrhagic shock and prevent multiple organ damage in vivo in animal experimental models.
in vivo
PG-931 (intravenous injection; 13-10 8 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock.
| Animal Model: | Wistar rats |
| Dosage: | 13-10 8 nmol/kg |
| Administration: | Intravenous injection; single dose |
| Result: | Exhibitd an anti-shock effect occurred at nanomolar doses. |
target
IC50: 0.58 nM (melanocortin 4 receptor)IC50: 2.4 nM (melanocortin 5 receptor)IC50: 55 nM (melanocortin 3 receptor)
PG 931 Preparation Products And Raw materials
Raw materials
Preparation Products
PG 931 Suppliers
Global( 28)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
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| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4855 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 6756 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 13355716090 | Sales@gotopbio.com | China | 2855 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-88211921 15572296305 | sales4@gotopbio.com | China | 5128 | 58 |
PG 931
L-Valinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-prolyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysyl-L-prolyl-, (2→7)-lactam
Ac-Nle-cyclo（Asp-Pro-D-Phe-Arg-Trp-Lys)-Pro-Val-NH2
667430-81-1
C59H85N15O11