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ChemicalBook >> CAS DataBase List >>AM095

AM095

CAS No.
1228690-36-5
Chemical Name:
AM095
Synonyms
CS-1624;AM095 (free acid);AM-095 (free base);AM 095 (parent compound);AM095 free acid, 10 mM in DMSO;AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID;[4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid;2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid;[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-;(R)-2-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid
CBNumber:
CB42624905
Molecular Formula:
C27H24N2O5
Molecular Weight:
456.49
MDL Number:
MFCD22665734
MOL File:
1228690-36-5.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22

AM095 Properties

Boiling point 641.9±55.0 °C(Predicted)
Density 1.278±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic
form Powder
pka 4.21±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P280-P301+P312-P362+P364
HS Code  2934999090

AM095 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22141 AM095 ≥98% 1228690-36-5 5mg $81 2024-03-01 Buy
Cayman Chemical 22141 AM095 ≥98% 1228690-36-5 10mg $152 2024-03-01 Buy
Cayman Chemical 22141 AM095 ≥98% 1228690-36-5 25mg $356 2024-03-01 Buy
ApexBio Technology A3167 AM-095freebase 1228690-36-5 50mg $488 2021-12-16 Buy
ChemScene CS-1129 AM095freeacid 99.28% 1228690-36-5 50mg $540 2021-12-16 Buy
Product number Packaging Price Buy
22141 5mg $81 Buy
22141 10mg $152 Buy
22141 25mg $356 Buy
A3167 50mg $488 Buy
CS-1129 50mg $540 Buy

AM095 Chemical Properties,Uses,Production

Biological Activity

am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].

in vitro

am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].

in vivo

am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].

target

LPA1 receptor

References

[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.

859169-20-3
1228690-36-5
Synthesis of AM095 from 4-(ethoxycarbonylmethyl)phenylboronic acid, pinaco
Global( 77)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
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Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58

View Lastest Price from AM095 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AM095 free acid pictures 2024-11-19 AM095 free acid
1228690-36-5
 US $33.00-76.00 / mg 99.88% 10g TargetMol Chemicals Inc.
AM095 free acid pictures 2024-11-19 AM095 free acid
1228690-36-5
 US $33.00-76.00 / mg 99.88% 10g TargetMol Chemicals Inc.
AM095 pictures 2019-09-02 AM095
1228690-36-5
 US $7.00 / KG 1KG 99% JD 491 Career Henan Chemical Co
  • AM095 free acid pictures
  • AM095 free acid
    1228690-36-5
  • US $33.00-76.00 / mg
  • 99.88%
  • TargetMol Chemicals Inc.
  • AM095 free acid pictures
  • AM095 free acid
    1228690-36-5
  • US $33.00-76.00 / mg
  • 99.88%
  • TargetMol Chemicals Inc.
  • AM095 pictures
  • AM095
    1228690-36-5
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

AM095 Spectrum

AM 095 (parent compound) 2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid AM-095 (free base) AM095 (free acid) [4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID CS-1624 [1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]- AM 095,Inhibitor,AM095 free acid,AM-095 free acid,inhibit,AM095,Lysophospholipid Receptor,AM-095,LPL Receptor (R)-2-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid AM095 free acid, 10 mM in DMSO 1228690-36-5 228690-36-5