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ChemicalBook >> CAS DataBase List >>1H-1-Ethyl Candesartan Cilexetil

1H-1-Ethyl Candesartan Cilexetil

CAS No.
914613-35-7
Chemical Name:
1H-1-Ethyl Candesartan Cilexetil
Synonyms
Candesartan EP Imp E;Candesartan Impurity 2;Candesartan EP Impurity-E;1H-1-Ethyl Candesartan Cilexetil;Candesartan Cilexetil impurity E;Candesartan Cilexetil EP IMpurity E;Candesartan Cilexetil Impurity 5(EP Impurity E);Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E);2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-;Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)
CBNumber:
CB42508599
Molecular Formula:
C35H38N6O6
Molecular Weight:
638.71282
MDL Number:
MFCD18382323
MOL File:
914613-35-7.mol
MSDS File:
SDS
Last updated:2024-11-13 11:39:26

1H-1-Ethyl Candesartan Cilexetil Properties

Melting point 90-93°C
Boiling point 842.0±75.0 °C(Predicted)
Density 1.32
storage temp. Refrigerator
solubility ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
form crystalline solid
pka 3.95±0.10(Predicted)
FDA UNII IN72J7R432

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning

1H-1-Ethyl Candesartan Cilexetil price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17912 1H-1-ethyl Candesartan Cilexetil ≥98% 914613-35-7 1mg $57 2024-03-01 Buy
Cayman Chemical 17912 1H-1-ethyl Candesartan Cilexetil ≥98% 914613-35-7 5mg $220 2024-03-01 Buy
Cayman Chemical 17912 1H-1-ethyl Candesartan Cilexetil ≥98% 914613-35-7 10mg $330 2024-03-01 Buy
TRC E900870 1H-1-EthylCandesartanCilexetil 914613-35-7 10mg $180 2021-12-16 Buy
ApexBio Technology C5023 1H-1-ethylCandesartanCilexetil 914613-35-7 10mg $374 2021-12-16 Buy
Product number Packaging Price Buy
17912 1mg $57 Buy
17912 5mg $220 Buy
17912 10mg $330 Buy
E900870 10mg $180 Buy
C5023 10mg $374 Buy

1H-1-Ethyl Candesartan Cilexetil Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Candesartan Cilexetil Impurity E (PHARMEUROPA).

Biological Activity

1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].

References

[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.

1H-1-Ethyl Candesartan Cilexetil Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11922 58
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+8618627948422 sale@hdimpurity.com China 3389 58
QUALITY CONTROL SOLUTIONS LTD. 		0755-66853366; 13670046396 ORDERS@QCSRM.COM China 24326 58
Guangzhou PI PI Biotech Inc 020-81716320 +86-13602409664 Sales@pipitech.com China 3633 55
Hunan Zengda Biological Technology Co., LTD 18711085600 1652923704@qq.com China 4582 58

View Lastest Price from 1H-1-Ethyl Candesartan Cilexetil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-1-ethyl Candesartan Cilexetil pictures 2024-11-12 1H-1-ethyl Candesartan Cilexetil
914613-35-7
 US $35.00-136.00 / mg 97.95% 10g TargetMol Chemicals Inc.
Candesartan Cilexetil EP Impurity E pictures 2024-09-20 Candesartan Cilexetil EP Impurity E
914613-35-7
 US $0.00-0.00 / mg 10mg 0.98 10g ShenZhen H&D Pharmaceutical Technology Co., LTD

1H-1-Ethyl Candesartan Cilexetil Spectrum

1H-1-Ethyl Candesartan Cilexetil 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]- Candesartan Cilexetil EP IMpurity E Candesartan Cilexetil EP Impurity EQ: What is Candesartan Cilexetil EP Impurity E Q: What is the CAS Number of Candesartan Cilexetil EP Impurity E Q: What is the storage condition of Candesartan Cilexetil EP Impurity E Q: What are the applications of Candesartan Cilexetil EP Impurity E Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog) 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate Candesartan EP Imp E Candesartan Cilexetil Impurity 5(EP Impurity E) Candesartan Impurity 2 Candesartan Cilexetil impurity E Candesartan Cilexetil,1H1ethyl Candesartan Cilexetil,Inhibitor,1H 1 ethyl Candesartan Cilexetil,inhibit Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E) (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1- ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7- carboxylate 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'- (1-ethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)- 1H-benzo[d]imidazole-7-carboxylate Candesartan EP Impurity-E 914613-35-7 Aromatics Heterocycles Impurities Intermediates & Fine Chemicals Pharmaceuticals