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DDD85646
- CAS No.
- 1215010-55-1
- Chemical Name:
- DDD85646
- Synonyms
- DDD85646;DDD 85646 (DDD85646);DDD85646 Hydrochloride;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
- CBNumber:
- CB34666388
- Molecular Formula:
- C21H24Cl2N6O2S
- Molecular Weight:
- 495.43
- MDL Number:
- MOL File:
- 1215010-55-1.mol
Last updated:2024-11-19 23:02:33
| Melting point | >215°C (dec.) |
|---|---|
| Boiling point | 684.3±65.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| pka | 7.04±0.50(Predicted) |
| color | Off-White to Yellow |
| FDA UNII | DTX5CVK89G |
DDD85646 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13839 | DDD85646 ≥98% | 1215010-55-1 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 13839 | DDD85646 ≥98% | 1215010-55-1 | 5mg | $410 | 2024-03-01 | Buy |
| Cayman Chemical | 13839 | DDD85646 ≥98% | 1215010-55-1 | 10mg | $672 | 2024-03-01 | Buy |
| TRC | D195323 | DDD85646 | 1215010-55-1 | 2.5mg | $265 | 2021-12-16 | Buy |
| Usbiological | 445831 | DDD85646 | 1215010-55-1 | 1mg | $410 | 2021-12-16 | Buy |
DDD85646 Chemical Properties,Uses,Production
Description
DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).
Uses
DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT).
DDD85646 Preparation Products And Raw materials
Raw materials
Preparation Products
DDD85646 Suppliers
Global( 34)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4566 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7296 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 924 | 58 |
DDD85646
DDD 85646
(DDD85646)
Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-
DDD85646 Hydrochloride
African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide
1215010-55-1
C21H24Cl2N6O2S