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ChemicalBook >> CAS DataBase List >>N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

CAS No.
17328-16-4
Chemical Name:
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
Synonyms
TC-E 5003;N'-(Sulfonyldi-4;TC-E 5003 (NSC-30176);1-phenylene)bis(2-chloroacetamide);Bis[4-(chloroacetylamino)phenyl] sulfone;4',4'''-Sulfonylbis(α-chloroacetanilide);N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide);N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);N,N'-[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide);Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2-chloro-
CBNumber:
CB32217920
Molecular Formula:
C16H14Cl2N2O4S
Molecular Weight:
401.26
MDL Number:
MFCD00028183
MOL File:
17328-16-4.mol
Last updated:2024-11-07 13:31:19

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Properties

Melting point 191-192 °C
Boiling point 704.2±60.0 °C(Predicted)
Density 1.504±0.06 g/cm3(Predicted)
storage temp. -20°C (des.)
solubility Soluble in DMSO (up to 50 mg/ml).
form solid
pka 11.56±0.70(Predicted)
color Brown
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S718114 4'',4''''-SULFONYLBIS(2-CHLOROACETANILIDE) AldrichCPR 17328-16-4 5MG $139 2024-03-01 Buy
Cayman Chemical 17718 TC-E 5003 ≥95% 17328-16-4 25mg $44 2024-03-01 Buy
Cayman Chemical 17718 TC-E 5003 ≥95% 17328-16-4 50mg $70 2024-03-01 Buy
Cayman Chemical 17718 TC-E 5003 ≥98% 17328-16-4 500mg $384 2024-03-01 Buy
Cayman Chemical 17718 TC-E 5003 ≥95% 17328-16-4 100mg $130 2024-03-01 Buy
Product number Packaging Price Buy
S718114 5MG $139 Buy
17718 25mg $44 Buy
17718 50mg $70 Buy
17718 500mg $384 Buy
17718 100mg $130 Buy

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Chemical Properties,Uses,Production

Description

TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.

Uses

NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.

References

1) Bissinger?et al. (2011),?Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem.,?19?3717

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 64)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 17159 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10032 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30241 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TC-E 5003 pictures 2024-11-08 TC-E 5003
17328-16-4
 US $39.00-97.00 / mg 97.01% 10g TargetMol Chemicals Inc.
  • TC-E 5003 pictures
  • TC-E 5003
    17328-16-4
  • US $39.00-97.00 / mg
  • 97.01%
  • TargetMol Chemicals Inc.

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Spectrum

17328-16-4(N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide))Related Search:

4',4'''-Sulfonylbis(α-chloroacetanilide) Bis[4-(chloroacetylamino)phenyl] sulfone N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) TC-E 5003 N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide) N'-(Sulfonyldi-4 1-phenylene)bis(2-chloroacetamide) TC-E 5003 (NSC-30176) N,N'-[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide) Inhibitor,TC-E 5003,hPRMT1,inhibit,Histone Methyltransferase,TLR4 signaling,anti-inflammatory,TCE 5003,TC E 5003 Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2-chloro- N,N'-(Sulfonylbis(4,1-phenylene))bis(2-chloroacetamide) 17328-16-4