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ChemicalBook >> CAS DataBase List >>Citarinostat

Citarinostat

CAS No.
1316215-12-9
Chemical Name:
Citarinostat
Synonyms
CS-1760;HDAC-IN-2;Citarinostat;ACY-241(CITARINOSTAT);Citarinostat (ACY-241);Citarinostat(ACY-241,HDAC-IN-2);ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT.;2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-;2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide
CBNumber:
CB22723105
Molecular Formula:
C24H26ClN5O3
Molecular Weight:
467.95
MDL Number:
MFCD28023593
MOL File:
1316215-12-9.mol
Last updated:2024-11-19 20:33:22

Citarinostat Properties

Density 1.293±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥23.4 mg/mL in DMSO; insoluble in H2O; ≥4.87 mg/mL in EtOH with ultrasonic
form solid
pka 9.47±0.20(Predicted)
color White to off-white
FDA UNII 441P620G3P

SAFETY

Risk and Safety Statements

Citarinostat price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26173 ACY-241 1316215-12-9 5mg $86 2024-03-01 Buy
Cayman Chemical 26173 ACY-241 1316215-12-9 25mg $315 2024-03-01 Buy
Cayman Chemical 26173 ACY-241 1316215-12-9 10mg $152 2024-03-01 Buy
TRC C585595 Citarinostat 1316215-12-9 25mg $305 2021-12-16 Buy
AK Scientific X3978 HDAC-IN-2 1316215-12-9 25mg $266 2021-12-16 Buy
Product number Packaging Price Buy
26173 5mg $86 Buy
26173 25mg $315 Buy
26173 10mg $152 Buy
C585595 25mg $305 Buy
X3978 25mg $266 Buy

Citarinostat Chemical Properties,Uses,Production

Description

ACY-241 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 2.6 nM). It is selective for HDAC6 over HDAC1-3, HDAC7, and HDAC9 (IC50s = 35, 45, 46, 7,300, and 137 nM, respectively), as well as HDAC4, HDAC5, and HDAC9 (IC50 = >20,000 nM for all). It reduces proliferation of A2780, TOV-21G, and MDA-MB-231 cells when used at a concentration of 3 μM and completely inhibits it and induces apoptosis at a concentration of 10 μM. ACY-241, when used in combination with paclitaxel , inhibits proliferation in MiaPaCa-2, TOV-21G, and T47D cells. It also reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at a dose of 50 mg/kg in combination with paclitaxel. ACY-241, in combination with the somatostatin receptor agonist pasireotide , reduces hepatorenal cystogenesis in a rat model of polycystic liver disease.

Uses

Citarinostat is a HDAC inhibitor.

References

[1]. quayle sn, almeciga-pinto i, tamang d, et al. selective hdac inhibition by ricolinostat (acy-1215) or acy-241 synergizes with imid® immunomodulatory drugs in multiple myeloma (mm) and mantle cell lymphoma (mcl) cells. in: proceedings of the 106th annual meeting of the american association for cancer research, 2015, philadelphia, pa. philadelphia (pa): aacr; cancer res 2015;75(15 suppl):abstract nr 5380.
[2]. huang p, almeciga-pinto i, jordan m, et al. selective hdac inhibition by acy-241 enhances the activity of paclitaxel in solid tumor models. in: proceedings of the 2015 aacr-nci-eortc international conference on molecular targets and cancer therapeutics; 2015 nov 5-9; boston, massachusetts. philadelphia (pa): aacr

Citarinostat Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58

View Lastest Price from Citarinostat manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Citarinostat pictures 2024-11-19 Citarinostat
1316215-12-9
 US $44.00-122.00 / mg 98.54% 10g TargetMol Chemicals Inc.
Citarinostat pictures 2019-12-23 Citarinostat
1316215-12-9
 US $1.00 / KG 1g Min98% HPLC g/kg /ton Career Henan Chemical Co
  • Citarinostat pictures
  • Citarinostat
    1316215-12-9
  • US $44.00-122.00 / mg
  • 98.54%
  • TargetMol Chemicals Inc.
  • Citarinostat pictures
  • Citarinostat
    1316215-12-9
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

Citarinostat Spectrum

2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide Citarinostat Citarinostat (ACY-241) ACY-241(CITARINOSTAT) 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide 5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]- HDAC-IN-2 Citarinostat(ACY-241,HDAC-IN-2) (Z)-2-((2-chlorophenyl)(phenyl)amino)-N-((Z)-7-hydroxy-7-(hydroxyimino)heptyl)pyrimidine-5-carbimidic acid (Z)-2-((2-CHLOROPHENYL)(PHENYL)AMINO)-N-((Z)-7-HYDROXY-7-(HYDROXYIMINO)HEPTYL)PYRIMIDINE-5-CARBIMIDIC ACID;HDAC-IN-2 CS-1760 ACY-241; ACY 241; ACY241; HDAC-IN-2; CITARINOSTAT. N-(6-(hydroxycarbamoyl)hexyl)-2-(N-(2-chlorophenyl)-N-phenylamino)pyrimidine-5-carboxamide 1316215-12-9