A 967079
- CAS No.
- 1170613-55-4
- Chemical Name:
- A 967079
- Synonyms
- A 967079;A-967079, 10 mM in DMSO;A-967079, TRPA1 receptor antagonist;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
- CBNumber:
- CB22650391
- Molecular Formula:
- C12H14FNO
- Molecular Weight:
- 207.24
- MDL Number:
- MFCD20488058
- MOL File:
- 1170613-55-4.mol
- MSDS File:
- SDS
| Boiling point | 324.4±34.0 °C(Predicted) |
|---|---|
| Density | 1.03±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥12mg/mL |
| pka | 12.23±0.40(Predicted) |
| form | powder |
| color | white to tan |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
| InChI | InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+ |
| InChIKey | HKROEBDHHKMNBZ-CHBKHGQFSA-N |
| SMILES | C(/C1=CC=C(F)C=C1)=C(/C)\C(=N\O)\CC |
| FDA UNII | S15N98QQ2K |
| UNSPSC Code | 12352200 |
| NACRES | NA.25 |
A 967079 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0085 | A-967079 ≥98% (HPLC) | 1170613-55-4 | 5mg | $85.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0085 | A-967079 ≥98% (HPLC) | 1170613-55-4 | 25mg | $538 | 2024-03-01 | Buy |
| Cayman Chemical | 15207 | A-967079 ≥98% | 1170613-55-4 | 5mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 15207 | A-967079 ≥98% | 1170613-55-4 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 15207 | A-967079 ≥98% | 1170613-55-4 | 25mg | $286 | 2024-03-01 | Buy |
A 967079 Chemical Properties,Uses,Production
Description
A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable
Uses
A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.
Uses
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.
General Description
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
storage
+4°C
Advantages
(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime (A-967079) has shown impressive efficacy as an antagonist to TRPA1 and has multiple advantages over other compounds, including high selectivity, potency, and oral bioavailability. A-967079 has IC50 values of 67 and 289 nM for human and rat TRPA1 receptors, respectively. It displays 1000-fold selectivity for TRPA1 over other TRP channels, and >150-fold selectivity for over 75 other ion channels, enzymes and G-protein-coupled receptors. Oral administration of A-967079 in rats produced robust bioavailability and analgesic efficacy for TIH-induced pain response (i.e., sneezing, tearing, coughing, etc.) and osteoarthritic pain. Intravenous injection of A-967079 has shown to decrease the reactive gas response of wide dynamic range neurons (i.e., a second-order neuron that responds to more than one type of stimulus) and pain specific-neurons. Aditionally, A-967079 produces no known locomotor or cardiovascular effects, a common side effect of other TRP antagonists[2].
References
[1] McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.
[2] Obed A. Gyamfi . “Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry.” Journal of Pharmaceutical Analysis 10 2 (2020): Pages 157-163.
A 967079 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 | info@chuchangbiotech.com | China | 202 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Chuchang Biotech Co., Ltd. | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Biochempartner | 58 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Alfa Chemistry | 58 |
| InvivoChem | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
