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ChemicalBook >> CAS DataBase List >>4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

CAS No.
349085-82-1
Chemical Name:
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
Synonyms
CS-2460;GSK137647;GSK137647A;GSK137647A, >98%;FFA4 (GPR120) agonist GS137647A;FFA4 (GPR120) agonist GSK137647A;Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)-;GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
CBNumber:
CB22635143
Molecular Formula:
C16H19NO3S
Molecular Weight:
305.39
MDL Number:
MFCD02007969
MOL File:
349085-82-1.mol
MSDS File:
SDS
Last updated:2024-10-31 21:04:56

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Properties

Boiling point 438.1±55.0 °C(Predicted)
Density 1.214±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol.
form powder
pka 9.23±0.10(Predicted)
color white to beige
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference 349085-82-1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
NFPA 704
0
2 0

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1152 GSK137647A ≥98% (HPLC) 349085-82-1 5mg $118 2024-03-01 Buy
Sigma-Aldrich SML1152 GSK137647A ≥98% (HPLC) 349085-82-1 25mg $476 2024-03-01 Buy
Alfa Aesar H57808 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97% 349085-82-1 1g $255 2021-12-16 Buy
Alfa Aesar H57808 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97% 349085-82-1 250mg $80.6 2021-12-16 Buy
Cayman Chemical 17712 GSK137647A ≥98% 349085-82-1 5mg $62 2024-03-01 Buy
Product number Packaging Price Buy
SML1152 5mg $118 Buy
SML1152 25mg $476 Buy
H57808 1g $255 Buy
H57808 250mg $80.6 Buy
17712 5mg $62 Buy

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Chemical Properties,Uses,Production

Description

GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2

Uses

4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.

in vitro

gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1].

in vivo

gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2].

target

ffa4/gpr120

storage

Store at RT

References

1) Martin?et al. (2012),?Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res.,?53?2256 2) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 99)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific
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Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55

View Lastest Price from 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK137647A pictures 2024-10-31 GSK137647A
349085-82-1
US $30.00-77.00 / mg 99.87% 10g TargetMol Chemicals Inc.
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% pictures 2019-09-06 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
349085-82-1
US $1.00 / ASSAYS 1ASSAYS 95%~99% per week:100kg Career Henan Chemical Co
  • GSK137647A pictures
  • GSK137647A
    349085-82-1
  • US $30.00-77.00 / mg
  • 99.87%
  • TargetMol Chemicals Inc.

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Spectrum

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% GSK137647A GSK137647 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97% GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647 GSK137647A, >98% CS-2460 FFA4 (GPR120) agonist GS137647A Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)- FFA4 (GPR120) agonist GSK137647A 349085-82-1 API