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ChemicalBook >> CAS DataBase List >>Isopropyl unoprostone

Isopropyl unoprostone

CAS No.
120373-24-2
Chemical Name:
Isopropyl unoprostone
Synonyms
UF-021;Rescul;RESCULA;Unii-5m161S5o5p;ISOPROPY UNOPROSTONE;isopropyl unoprostone;UNOPROSTONE ISOPROPYL ESTER;Isopropyl unoprostone USP/EP/BP;Uroprostaglandin isopropyl ester;13,14-dihydro-15-keto-20-ethyl-pgf
CBNumber:
CB1392171
Molecular Formula:
C25H44O5
Molecular Weight:
424.61
MDL Number:
MFCD00886951
MOL File:
120373-24-2.mol
MSDS File:
SDS
Last updated:2024-10-28 23:16:16

Isopropyl unoprostone Properties

Boiling point 546.3±45.0 °C(Predicted)
Density 1.019±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Oil
pka 14.79±0.70(Predicted)
color Clear Colourless
CAS DataBase Reference 120373-24-2(CAS DataBase Reference)
FDA UNII 5M161S5O5P

SAFETY

Risk and Safety Statements

Isopropyl unoprostone price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16681 Unoprostone isopropyl ester ≥98% 120373-24-2 1mg $57 2024-03-01 Buy
Cayman Chemical 16681 Unoprostone isopropyl ester ≥98% 120373-24-2 5mg $257 2024-03-01 Buy
Cayman Chemical 16681 Unoprostone isopropyl ester ≥98% 120373-24-2 10mg $456 2024-03-01 Buy
Cayman Chemical 16681 Unoprostone isopropyl ester ≥98% 120373-24-2 50mg $1853 2024-03-01 Buy
TRC U800050 UnoprostoneIsopropylEster 120373-24-2 5mg $880 2021-12-16 Buy
Product number Packaging Price Buy
16681 1mg $57 Buy
16681 5mg $257 Buy
16681 10mg $456 Buy
16681 50mg $1853 Buy
U800050 5mg $880 Buy

Isopropyl unoprostone Chemical Properties,Uses,Production

Description

Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.

Description

Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F (PGF). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF on FP receptors.

Chemical Properties

Clear Colourless Oil

Originator

Ueno (Japan)

Uses

Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.

Uses

Antiglaucoma; used in treatment of ocular hypertension.

Definition

ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.

brand name

Rescuia

Hazard

A poison.

Isopropyl unoprostone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18780 58
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29884 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32112 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15354 58

View Lastest Price from Isopropyl unoprostone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Unoprostone isopropyl pictures 2024-10-28 Unoprostone isopropyl
120373-24-2
US $143.00-1140.00 / mg 10g TargetMol Chemicals Inc.
Isopropyl unoprostone pictures 2024-04-17 Isopropyl unoprostone
120373-24-2
US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
	Isopropyl unoprostone pictures 2019-07-06 Isopropyl unoprostone
120373-24-2
US $7.00 / KG 1KG 99% 200KG Career Henan Chemical Co
RESCULA UNOPROSTONE ISOPROPYL ESTER isopropyl unoprostone 9ALPHA,11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID, ISOPROPYL ESTER (5z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-5-heptenoic acid 1-methylethyl ester 13,14-dihydro-15-keto-20-ethyl-pgf 13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopenthyl]-5-heptenoic Acid Isopropyl Ester Rescul UF-021 ISOPROPY UNOPROSTONE 13,14-Dihydro-15-keto-20-ethyl-pgf2 5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-, 1-methylethyl ester, (5Z)- Unii-5m161S5o5p (5Z)-7-[(1R, 2R, 3R, 5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid 13,14-Dihydro-15-keto-20-ethyl-PGF2 α isopropyl ester 13,14-dihydro-15-keto-20-ethyl-PGF2α isopropyl ester, (5Z)-7-[(1R, 2R, 3R, 5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid propan-2-yl ester Uroprostaglandin isopropyl ester Isopropyl unoprostone USP/EP/BP 120373-24-2 C25H44O5 Prostaglandin Intermediates & Fine Chemicals Pharmaceuticals Prostaglandins Chiral Reagents