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ChemicalBook >> CAS DataBase List >>OTSSP 167 hydrochloride

OTSSP 167 hydrochloride

CAS No.
1431697-89-0
Chemical Name:
OTSSP 167 hydrochloride
Synonyms
OTS167;CS-1832;CS-1147;OTSSP167;OTSSP 167;OTSSP-167;MELK inhibitor;OTSSP167 (OTS167);OTSSP167 (CS-1147);OTSSP167 (Free base)
CBNumber:
CB12666672
Molecular Formula:
C25H28Cl2N4O2
Molecular Weight:
487.42
MDL Number:
MFCD23160047
MOL File:
1431697-89-0.mol
Last updated:2024-11-19 20:33:22

OTSSP 167 hydrochloride Properties

storage temp. Store at -20°C
solubility insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form solid
color Light yellow to yellow
FDA UNII VY778IXU5T

OTSSP 167 hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC O713000 OTSSP167 1431697-89-0 2.5mg $165 2021-12-16 Buy
AK Scientific 2618AH 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone 1431697-89-0 2mg $232 2021-12-16 Buy
ApexBio Technology B1321 OTSSP167 1431697-89-0 10mg $240 2021-12-16 Buy
AK Scientific 2618AH 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone 1431697-89-0 10mg $424 2021-12-16 Buy
Biosynth Carbosynth BO170790 OTS 167 1431697-89-0 50mg $472.5 2021-12-16 Buy
Product number Packaging Price Buy
O713000 2.5mg $165 Buy
2618AH 2mg $232 Buy
B1321 10mg $240 Buy
2618AH 10mg $424 Buy
BO170790 50mg $472.5 Buy

OTSSP 167 hydrochloride Chemical Properties,Uses,Production

Uses

OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor.

Definition

ChEBI: 4-[7-acetyl-8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1H-1,5-naphthyridin-2-ylidene]-2,6-dichloro-1-cyclohexa-2,5-dienone is a naphthyridine derivative.

Biological Activity

otssp167 is an inhibitor of maternal embryonic leucine zipper kinase (melk) with ic50 value of 0.41nm [1].melk is a member of the ampk serine/threonine kinase family and is involved in the mammalian embryonic development. it plays roles in cancer cell growth and formation or maintenance of cancer stem cells. otssp167 is a small-molecule inhibitor and can inhibit melk’s activity effectively and selectively. otssp167 inhibits cell proliferation of a variety of cancer cell lines including a549, t47d, du4475 and 22rv1. the ic50 values are 6.7nm, 4.3nm, 2.3nm and 6nm, respectively. in mice bearing mda-mb-231 xenograft, administration of otssp167 inhibits 70% tumor growth at dose of 20 mg/kg. besides that, otssp167 is also found to have effects on psma1 and dbnl which are the novel substrates of melk. it inhibits the phosphorylation of psma1 and dbnl causes the subsequent suppression of mammosphere formation [1].

target

MELK

References

[1] chung s, suzuki h, miyamoto t, et al. development of an orally-administrative melk-targeting inhibitor that suppresses the growth of various types of human cancer. oncotarget, 2012, 3(12): 1629.

OTSSP 167 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 74)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from OTSSP 167 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
OTSSP167 pictures 2024-11-19 OTSSP167
1431697-89-0
 US $34.00-80.00 / mg 99.47% 10g TargetMol Chemicals Inc.
OTSSP167 pictures 2020-01-13 OTSSP167
1431697-89-0
 US $1.00 / g 1g 99% 1ton Career Henan Chemical Co
  • OTSSP167 pictures
  • OTSSP167
    1431697-89-0
  • US $34.00-80.00 / mg
  • 99.47%
  • TargetMol Chemicals Inc.
  • OTSSP167 pictures
  • OTSSP167
    1431697-89-0
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

OTSSP 167 hydrochloride Spectrum

1431697-89-0(OTSSP 167 hydrochloride)Related Search:

MELK inhibitor OTSSP 167 hydrochloride OTSSP167 (hydrochloride) OTSSP-167 hydrochloride OTSSP 167 OTSSP167 OTSSP-167 OTSSP167 (CS-1147) OTSSP167 (Free base) 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone OTS167 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((1r,4r)-4-((dimethylamino)methyl)cyclohexylamino)-1,5-naphthyridin-3-yl)ethanone 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone OTSSP167 hcl CS-1832 1-(8-((1R,4R)-4-((Dimethylamino)methyl)cyclohexylamino)-2-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-7-yl)ethanone CS-1147 Ethanone, 1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]- OTSSP167 (OTS167) inhibit,Maternal embryonic leucine zipper kinase,OTS 167,Inhibitor,OTS-167,MELK,OTSSP167,OTSSP 167,OTSSP-167 1431697-89-0 C25H28Cl2N4O2 Inhibitors API