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ChemicalBook >> CAS DataBase List >>GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

CAS No.
217082-58-1
Chemical Name:
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Synonyms
APELIN-13;QRPRLSHKGPMPF;PREPRO-65-77-APELIN;Apelin (1-13) (human);APELIN-13 (HUMAN, BOVINE);apelin-13 trifluoroacetate salt;APELIN-13 (HUMAN, BOVINE, MOUSE, RAT);Apelin-13 trifluoroacetate salt >=95%;Apelin-13, human, bovine, mouse, rat (2);GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
CBNumber:
CB0671552
Molecular Formula:
C69H111N23O16S
Molecular Weight:
1550.83
MDL Number:
MFCD02094627
MOL File:
217082-58-1.mol
Last updated:2024-03-27 11:49:37

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble in PBS (pH 7.2) at approximately 10 mg/ml.
pka 3.56±0.10(Predicted)
form Lyophilized powder
Sequence H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
FDA UNII GF5K6G6AH3

SAFETY

Risk and Safety Statements

WGK Germany  3

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A6469 Apelin-13 trifluoroacetate salt ≥95% 217082-58-1 1mg $202.8 2024-03-01 Buy
Alfa Aesar J66620 Apelin-13, human, bovine 217082-58-1 1mg $147 2023-06-20 Buy
Alfa Aesar J66620 Apelin-13, human, bovine 217082-58-1 0.5mg $73.4 2021-12-16 Buy
Cayman Chemical 13523 Apelin-13 ≥95% 217082-58-1 1mg $57 2024-03-01 Buy
Cayman Chemical 13523 Apelin-13 ≥95% 217082-58-1 5mg $249 2024-03-01 Buy
Product number Packaging Price Buy
A6469 1mg $202.8 Buy
J66620 1mg $147 Buy
J66620 0.5mg $73.4 Buy
13523 1mg $57 Buy
13523 5mg $249 Buy

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Chemical Properties,Uses,Production

Uses

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the EC50 values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively). It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity. Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.

Uses

Apelin-13 trifluoroacetate salt has been used to determine whether apelin promotes progression of diabetic nephropathy (DN) by inducing podocyte dysfunction. It has also been used to examine the effects of apelin on myocardial infarction (MI) injury and underlying mechanisms.

Uses

An endogenous ligand of Apelin Receptor (APLNR/APJ receptor) that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity.

Definition

ChEBI: Apelin-13 is a 13 amino acid oligopeptide which is the ligand for the apelin receptor (also known as the APJ receptor). It exhibits hypotensive and neuroprotective effects, and may be a potential prognostic biomarker for acute ischemic stroke and multiple sclerosis. It has a role as an antihypertensive agent, a biomarker, an autophagy inhibitor, a neuroprotective agent and a human metabolite. It is a conjugate base of an apelin-13(3+).

General Description

Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Biological Activity

apelin-13 is an endogenous ligand of the apj receptor.the apelin receptor apj, one of a group of g-proteincoupled receptors (gpcr), have recently been paired with their cognate peptide ligands using ‘‘reverse pharmacology’’, and functional evidence suggests a role for this receptor in the regulation of cardiovascular function, fluid homeostasis, and as a coreceptor for hiv infection.

Biochem/physiol Actions

Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.

in vitro

apelin-13 was identified as an endogenous ligand of the apj receptor, which could activate this g protein-coupled receptor with an ec50 value of 0.37 nm. in addition, the ec50 values for apelin-17 and apelin-36 have been found to be 2.5 and 20 nm, respectively [1].

in vivo

in a previous study, urethane anaesthetised, paralysed and ventilated male sd rats were used to investigate the action of apelin-13 directly microinjected into the nucleus tractus solitarius (nts) and the rostral ventrolateral medulla (rvlm) on arterial pressure and phrenic nerve activity. results showed that apelin-13 microinjections into the nts led to either apnea or decreased phrenic nerve discharge amplitude by up to 30%. in the rvlm, apelin-13 caused increase in phrenic nerve discharge amplitude depending on the exact site of injection [2].

IC 50

0.37 nm for gpcr

References

[1] lee, d. k.,cheng, r.,nguyen, t., et al. characterization of apelin, the ligand for the apj receptor. journal of neurochemistry 74, 34-41 (2000).
[2] seyedabadi m, goodchild ak, pilowsky pm. site-specific effects of apelin-13 in the rat medulla oblongata on arterial pressure and respiration. auton neurosci. 2002 oct 31;101(1-2):32-8.
[3] a g japp, n l cruden, g barnes, n van gemeren, j mathews, j adamson, n r johnston, m a denvir, i l megson, a d flapan, d e newby. acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. circulation 2010 april 27, 121 (16): 1818-27.

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Preparation Products And Raw materials

Raw materials

Preparation Products

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Suppliers

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Cellmano Biotech Limited 		0551-65326643 18156095617 info@cellmano.com China 999 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hangzhou Go Top Peptide Biotech 		0571-88211921 sales1@gotopbio.com CHINA 2609 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634 Cecilia@youngshechem.com China 2345 58

View Lastest Price from GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE pictures 2020-02-14 GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
217082-58-1
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Spectrum

apelin-13 trifluoroacetate salt Apelin-13, human, bovine, mouse, rat (2) Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM) Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH L-Phenylalanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl- QRPRLSHKGPMPF PREPRO-65-77-APELIN H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE APELIN-13 APELIN-13 (HUMAN, BOVINE) APELIN-13 (HUMAN, BOVINE, MOUSE, RAT) Apelin-13 (human, bovine, mouse, rat) H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH Apelin-13 trifluoroacetate salt >=95% GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE USP/EP/BP Apelin 13 triTFA(217082 58 1(free base)),Apelin13 triTFA(217082581(free base)) Apelin (1-13) (human) 217082-58-1 C69H111N23O16SC2F3O2 C69H111N23O16S Apelin receptor Peptide Elisa Kit-Mouse Elisa Kit