ChemicalBook >> CAS DataBase List >>TPCK
TPCK
- CAS No.
- 402-71-1
- Chemical Name:
- TPCK
- Synonyms
- TPCK;L-TPCK;TOS-PHE-CMK;Tos-L-Phe-CMK;TPCK USP/EP/BP;(-)-p-toluenesulfonamid;Tos-L-Phe-Chloromethane;TOS-PHE-CHLOROMETHYLKETONE;N-TOSYL-PHE-CHLOROMETHYLKETONE;Tosylphenylalanylchloromethane
- CBNumber:
- CB0354828
- Molecular Formula:
- C17H18ClNO3S
- Molecular Weight:
- 351.85
- MDL Number:
- MFCD00000935
- MOL File:
- 402-71-1.mol
- MSDS File:
- SDS
Last updated:2024-10-30 20:13:01
| Melting point | 106-108 °C(lit.) |
|---|---|
| Boiling point | 509.9±60.0 °C(Predicted) |
| Density | 1.1350 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: >10 mg/mL stable for several months at 4°C. |
| form | powder |
| pka | 8.71±0.50(Predicted) |
| color | white |
| BRN | 2895215 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 402-71-1 |
| FDA UNII | P598716LJT |
| EPA Substance Registry System | Benzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl- (402-71-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XT5613500 | |||||||||
| F | 10-19-21 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29350090 | |||||||||
| NFPA 704 |
|
TPCK price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T4376 | N-p-Tosyl-L-phenylalanine chloromethyl ketone ≥97% (TLC), powder | 402-71-1 | 1g | $249 | 2024-03-01 | Buy |
| Sigma-Aldrich | 616387 | N-p-Tosyl-L-phenylalanine chloromethyl ketone Irreversible inhibitor of chymotrypsin. | 402-71-1 | 250mg | $85.2 | 2024-03-01 | Buy |
| TCI Chemical | T2810 | N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone >95.0%(HPLC)(T) | 402-71-1 | 1g | $212 | 2021-12-16 | Buy |
| TCI Chemical | T2810 | N-(p-Toluenesulfonyl)-L-phenylalanyl Chloromethyl Ketone >95.0%(HPLC)(T) | 402-71-1 | 200mg | $72 | 2021-12-16 | Buy |
| Alfa Aesar | J60639 | N-(p-Toluenesulfonyl)-L-phenylalanine chloromethyl ketone | 402-71-1 | 5g | $619 | 2021-12-16 | Buy |
TPCK Chemical Properties,Uses,Production
Description
TPCK (402-71-1) is an irreversible inhibitor of the serine protease chymotrypsin.1 It also inhibits certain cysteine proteases (bromelain, ficin, papain).1 TPCK inhibited (IC50 = 5 μM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.2
Chemical Properties
white crystalline powder
Uses
N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
Definition
ChEBI: The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.
Biochem/physiol Actions
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli. Also blocks apoptosis initiated by Taxol (in MCF-7 human breast carcinoma cells).
Safety Profile
Experimental reproductive effects. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx, SOx, and Cl-.
References
1) Bond and Butler, (1987) Intracellular proteases; Annu. Rev. Biochem., 56 333 2) Grammer and Blenis (1996) The serine protease inhibitors, tosylphenylalanine chloromethylketone and tosyllysine chloromethylketone, potently inhibit pp70s6k activation; J. Biol. Chem., 271 23650
TPCK Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 138)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29885 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32063 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23225 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18166 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38463 | 58 | |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
View Lastest Price from TPCK manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-04 | TPCK
402-71-1
|
US $27.00-55.00 / mg | 96.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | Tosyl phenylalanyl chloromethyl ketone
402-71-1
|
US $1.00 / kg | 1kg | 95%-99% | 1000kg | Career Henan Chemical Co |
-
- TPCK
402-71-1
- US $27.00-55.00 / mg
- 96.77%
- TargetMol Chemicals Inc.
-
- Tosyl phenylalanyl chloromethyl ketone
402-71-1
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co
402-71-1(TPCK)Related Search:
2-Methyl-4-isothiazolin-3-one
N-Cbz-Nortropinone
1-N-PHENYL-PIPERIDIN-4-ONE
N-BOC-L-leucylglycyl-arginine-p-nitroanilide hydrochloride
Ethyl N-benzoyl-L-tyrosinate
BAA
TOS-ARG-OME HCL
TLCK
N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride
Ethyl N-benzoyl-L-argininate hydrochloride
1of4
L-1-TOSYLAMIDE-2-PHENYLETHYL-CHLOROMETHYL KETONE
L-1-P-TOSYLAMINO-2-PHENYLETHYL CHLOROMETHYL KETONE
L-1-CHLORO-3-(4-TOSYLAMIDO)-4-PHENYL-2-BUTANONE
L-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE
L-1-4'-TOSYLAMINO-2-PHENYLETHYL CHLOROMETHYL KETONE
N-TOSYL-L-PHENYLALANINE CHLOROMETHYL KETONE
N-TOSYL-PHE-CHLOROMETHYLKETONE
N-TOSYLAMIDE PHENETHYL CHLOROMETHYLKETONE
P-TOLUENESULFONYL-L-PHENYLALANINE CHLOROMETHYL KETONE
N-ALPHA-TOSYL-PHE CHLOROMETHYL KETONE
N-ALPHA-P-TOSYL-L-PHENYLALANINE CHLOROMETHYIKETONE
(S)-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE
(S)-1-CHLORO-4-PHENYL-3-TOSYLAMIDO-2-BUTANONE
TOS-PHE-CHLOROMETHYLKETONE
TOS-PHE-CMK
TOSYL-L-PHENYLALANINE CHLOROMETHYL KETONE
TOSYL-L-PHENYLALANYL-CHLOROMETHANE
TPCK
(-)-p-toluenesulfonamid
l-1-tosylamido-2-phenylethylchloromethylketone
N-Tosyl-L-phenylalanine Chloromethyl Ketone(TPCK)
L-1-CHLORO-3-TOSYLAMIDO-4-PHENYL-2-BUTANONE RESEARCH GRADE
TPCK (N-TOSYL-L-PHENYLALANINE CHLOROMETH YL KETONE) \ PROTEASE INHIBITOR
N-p-Tosyl-L-phenylalanine chloromethyl ketone,(S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone, (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone, TPCK, Tosyl-L-phenylalanyl-chloromethane
N-(p-Toluenesulfonyl)-L-phenylalanyl ChloroMethyl Ketone
(S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide
N-Tosyl-L-phenylalanyl Chloromethyl Ketone
TPCK
N-α-Tosyl-L-phenylalanylchloromethane
TPCK (Tosyl Phenylalanyl ChloroMethyl ketone
Chloro-3-tosylaMido-4-phenyl-2-butanone research grade
N- (p-toluenesulfonyl) -L- phenylalanyl chloride ketone (TPCK)
alpha-N-Tosyl-L-phenylalanine chloromethyl ketone
N-alpha-Tosyl-L-phenylalanylchloromethane
Tosylphenylalanylchloromethane
N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK)
N-(p-Toluenesulfonyl)-L-phenylalanine chloromethyl ketone
L-1-4'-Tosylamino-2-phenylethylechloromethyleketone
N-tosyl-L-phenylalanyl chloromethyl ketone
Tos-L-Phe-CMK
Tosyl-L-Phenylalanine chloromethylketone≥ 98% (TLC)
(S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone, (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone, Tosyl-L-phenylalanyl-chloromethane, TPCK
N-[(S)-α-(Chloroacetyl)phenethyl]-4-methylbenzenesulfonamide
N-p-Tosyl-L-phenylalanyl chloromethane
N-p-Tosyl-L-phenylalanyl chloromethyl ketone
Tos-L-Phe-Chloromethane
L-1-4'-Tosylamino-2-phenylethyl chloromethyl ketoneTPCK
l-n-(alpha-(chloroacetyl)phenethyl)-p-toluenesulfonamide
tosylphenylalanylchloromethylketone
L-chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone
L-1-P-TOSYLAMINO-2-PHENYLETHYL CHLORO-METHYL KETONE, 99+%
L-1-4'-Tosylamino-2-phenylethyl chloromethyl ketone, 99+%
Chloro-3-tosylamido-4-phenyl-2-butanone
Benzenesulfonamide, N-(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl-4-methyl-
n-p-tosyl-l-phenylalanine chloromethyl ketone
L-1-4-Tosylamido-2-phenylethyl chloromethyl ketone.
L-1-PARA-TOSYLAMINO-2-PHENYLETHYLCHLOROMETHYLKETONE
L-1-TOSYLAMIDO-2-PHENYLETHYLCHLOROETHYLKETONE
NALPHA-(4-Toluenesulfonyl)-L-phenylalanine chloromethyl ketone
TOSYL-L-PHENYLALANINE-CHLOROMETHYL KETONE (TPCK)