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ChemicalBook >> CAS DataBase List >>ML216

ML216

CAS No.
1430213-30-1
Chemical Name:
ML216
Synonyms
ML216;CS-1561;CID49852229;CID 49852229;CID-49852229;ML216(CID4985229);ML216(CID-49852229);ML 216; ML-216; CID-49852229; CID49852229; CID 49852229;1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure;N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea
CBNumber:
CB02715652
Molecular Formula:
C15H9F4N5OS
Molecular Weight:
383.32
MDL Number:
MFCD24849400
MOL File:
1430213-30-1.mol
MSDS File:
SDS
Last updated:2024-11-17 16:00:36

ML216 Properties

Density 1.583±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)
pka 6.40±0.50(Predicted)
form powder
color light orange to dark orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

ML216 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0661 ML216 ≥98% (HPLC) 1430213-30-1 5MG $89.4 2024-03-01 Buy
Sigma-Aldrich SML0661 ML216 ≥98% (HPLC) 1430213-30-1 25MG $361 2024-03-01 Buy
Cayman Chemical 15186 ML-216 ≥98% 1430213-30-1 1mg $32 2024-03-01 Buy
Cayman Chemical 15186 ML-216 ≥98% 1430213-30-1 5mg $68 2024-03-01 Buy
Cayman Chemical 15186 ML-216 ≥98% 1430213-30-1 10mg $120 2024-03-01 Buy
Product number Packaging Price Buy
SML0661 5MG $89.4 Buy
SML0661 25MG $361 Buy
15186 1mg $32 Buy
15186 5mg $68 Buy
15186 10mg $120 Buy

ML216 Chemical Properties,Uses,Production

Description

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.

Uses

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.[Cayman Chemical]

Uses

ML216 has been used in cell proliferation assays.

Definition

ChEBI: 1-[4-fluoro-3-(trifluoromethyl)phenyl]-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea is a member of ureas.

Biochem/physiol Actions

ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase, a member of the RecQ DNA helicase family. Bloom′s syndrome, caused by a mutation in BLM, is associated with susceptibility to cancer, growth retardation, immunodeficiency, sunlight sensitivity, and fertility defects. ML216 is selective for BLM over other members of the RecQ family, especially in vivo, and appears to act at the BLM-nucleic acid substrate binding site, inhibiting DNA binding and blocking BLM′s helicase activity. ML216 could be useful in studies of tumor cells depending on the ALT (alternative lengthening of telomeres) mechanism for telomere maintenance rather than on telomerase, which are proposed to be susceptible to BLM inhibition.

ML216 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32951 60
Chengdu Feibo Pharm Technology Co., Ltd
+86 028-84641798 15982321820 abby@arkpharm.com China 10925 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32080 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38470 58
Chemtour Biotech Co., Ltd
+8617327281506 market@chemtour.com China 1460 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58

View Lastest Price from ML216 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ML216 pictures 2024-11-17 ML216
1430213-30-1
US $57.00-136.00 / mg 98.12% 10g TargetMol Chemicals Inc.
  • ML216 pictures
  • ML216
    1430213-30-1
  • US $57.00-136.00 / mg
  • 98.12%
  • TargetMol Chemicals Inc.

ML216 Spectrum

ML216 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea CID 49852229 CID49852229 CID-49852229 ML 216; ML-216; CID-49852229; CID49852229; CID 49852229 CS-1561 ML216(CID-49852229) ML216(CID4985229) 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]- helicase,CID 49852229,WRN,DNA,sister,inhibit,Anticancer,ML-216,anti-proliferative,DNA/RNA Synthesis,Inhibitor,chromatid,CID49852229,BLM,unwinding,toxicity,ML 216,ML216 1430213-30-1 C15H9F4N5OS