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ChemicalBook >> CAS DataBase List >>AZD 9668

AZD 9668

CAS No.
848141-11-7
Chemical Name:
AZD 9668
Synonyms
AZD9668;CS-1060;AZD-9668;AZD 9668;MPH-966);Avelestat;Alvelestat;Cavosonstat;Alvelestat-13C,d3;Avelestat (AZD9668)
CBNumber:
CB02668624
Molecular Formula:
C25H22F3N5O4S
Molecular Weight:
545.53
MDL Number:
MFCD26960961
MOL File:
848141-11-7.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

AZD 9668 Properties

Melting point 207-209°C
Boiling point 780.4±60.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
pka 11.00±0.20(Predicted)
form Solid
color White
FDA UNII 6Y5629322X
NCI Drug Dictionary alvelestat

SAFETY

Risk and Safety Statements

AZD 9668 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26083 AZD 9668 848141-11-7 5mg $109 2024-03-01 Buy
Cayman Chemical 26083 AZD 9668 848141-11-7 25mg $426 2024-03-01 Buy
Cayman Chemical 26083 AZD 9668 848141-11-7 1mg $44 2024-03-01 Buy
Cayman Chemical 26083 AZD 9668 848141-11-7 10mg $193 2024-03-01 Buy
TRC A794660 Avelestat 848141-11-7 25mg $475 2021-12-16 Buy
Product number Packaging Price Buy
26083 5mg $109 Buy
26083 25mg $426 Buy
26083 1mg $44 Buy
26083 10mg $193 Buy
A794660 25mg $475 Buy

AZD 9668 Chemical Properties,Uses,Production

Description

AZD 9668 is an orally bioavailable inhibitor of neutrophil elastase (IC50 = 12 nM for the human enzyme). It is greater than 600-fold selective for neutrophil elastase over other serine proteases, including human proteinase-3 and cathepsin G, bovine trypsin and chymotrypsin, and porcine pancreatic elastase. AZD 9668 inhibits neutrophil elastase activity in zymosan-stimulated isolated whole blood and in cell-associated assays (IC50s = 46 and 48 nM, respectively). It decreases the number of neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of smoke-induced airway inflammation when administered at a dose of 6 mg/kg. AZD 9668 also prevents airspace enlargement and small airway remodeling in a guinea pig model of chronic smoke-induced inflammation and emphysema.

Uses

Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.

target

NE

References

[1] stevens t, ekholm k, gränse m, et al. azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. journal of pharmacology and experimental therapeutics, 2011, 339(1): 313-320.

AZD 9668 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 98)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9311 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58

View Lastest Price from AZD 9668 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Alvelestat pictures 2024-11-19 Alvelestat
848141-11-7
 US $30.00-54.00 / mg 99.87% 10g TargetMol Chemicals Inc.
Alvelestat pictures 2021-07-13 Alvelestat
848141-11-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Alvelestat pictures 2021-07-10 Alvelestat
848141-11-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Alvelestat pictures
  • Alvelestat
    848141-11-7
  • US $30.00-54.00 / mg
  • 99.87%
  • TargetMol Chemicals Inc.
  • Alvelestat pictures
  • Alvelestat
    848141-11-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Alvelestat pictures
  • Alvelestat
    848141-11-7
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

AZD 9668 Spectrum

Alvelestat AZD 9668 AZD9668 AZD-9668 Avelestat (AZD9668) 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide Avelestat Alvelestat (AZD9668) 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-3-Pyridinecarboxamide 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide Avelestat (AZD9668) Cavosonstat 6-methyl-1-(3-methylphenyl)-5-(2-methylpyrazol-3-yl)-n-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxopyridine-3-carboxamide AZD9668; AZD-9668; AZD 9668 CS-1060 3-Pyridinecarboxamide, 1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]- MPH-966) Alvelestat-13C,d3 AZD-9668,Alvelestat,Elastase,AZD 9668,Inhibitor,inhibit 848141-11-7 Inhibitors