ChemicalBook >> CAS DataBase List >>N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- CAS No.
- 444731-75-3
- Chemical Name:
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- Synonyms
- BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib Impurity 34;Pazopanil impurity 14;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine
- CBNumber:
- CB02526159
- Molecular Formula:
- C14H14ClN5
- Molecular Weight:
- 287.75
- MDL Number:
- MFCD12923006
- MOL File:
- 444731-75-3.mol
- MSDS File:
- SDS
Last updated:2024-11-13 11:39:26
| Melting point | 167-173℃ |
|---|---|
| Boiling point | 524.4±35.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| pka | 2.82±0.30(Predicted) |
| Stability | Hygroscopic |
| CAS DataBase Reference | 444731-75-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H33611 | 6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole, 96% | 444731-75-3 | 500mg | $102 | 2023-06-20 | Buy |
| TRC | C380090 | N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine | 444731-75-3 | 1g | $155 | 2021-12-16 | Buy |
| TRC | C380090 | N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine | 444731-75-3 | 10g | $1210 | 2021-12-16 | Buy |
| Matrix Scientific | 139007 | N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 95%+ | 444731-75-3 | 1g | $1554 | 2021-12-16 | Buy |
| Matrix Scientific | 139007 | N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 95%+ | 444731-75-3 | 2.500g | $3386 | 2021-12-16 | Buy |
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Uses,Production
Chemical Properties
Light Beige to Beige Solid
Uses
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Synthesis
A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).
Synthesis of N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine from 2,4-Dichloropyrimidine and 2H-Indazol-6-amine, N,2,3-trimethyl-
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 199)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | 790226113@qq.com | China | 52 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20284 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 2691 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9087 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
View Lastest Price from N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-20 | N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
444731-75-3
|
US $150.00 / kg | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-11-26 | N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
444731-75-3
|
US $0.00 / kg | 1kg | 98% | ton | Nanjing Fred Technology Co., Ltd | |
 |
2024-10-31 | N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
444731-75-3
|
US $0.00 / g | 10g | 98% | 10tons | Yangzhou Qinyuan Pharmatech Co.,ltd |
-
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
444731-75-3
- US $150.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
444731-75-3
- US $0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
444731-75-3
- US $0.00 / g
- 98%
- Yangzhou Qinyuan Pharmatech Co.,ltd
444731-75-3(N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine)Related Search:
1,3-DiMethyl-6-aMino-1H-indazole
4(1H)-Pyrimidinone, 2-chloro- (9CI)
5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide
2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
5-BROMO-3-METHYLINDOLE
Pazopanib Impurity 10
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Pazopanib-d6
2,3-dimethyl-2H-indazol-6-amine hydrochloride
Pazopanib Impurity 9
1of4
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine
2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
6-[N-(2-chloro-4-pyriMidinyl)MethylaMino]-2,3-diMethyl-2H-indazole, 96%
N-(2-ChloropyriMidin-4-yl)-N-Methyl-2,3-diMethyl-2H-indazol-6-aMine
2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine
BNKY007-PZ02
2H-indazole-6-aMine，N-(2-chloro
-4-pyrimidinyl)-N,2,3-trimethyl-
Pazopanib Impurity 22
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine
N-(2- chloropyrimidine-4- group)- N- methyl-2,3-dimethyl-2 H- indazole-6-amine
6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole,96%
N-(2-chloropyrimidine-4-yl) -N-methyl-2, 3-dimethyl-2H-indazol-6-amine
Pazopanib intermediate
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine ISO 9001：2015 REACH
(2-Chloro-pyrimidin-4-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...
TIANFU-CHEM - N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
Pazopanib ( PAZ ) N - Methyl compound
N - (2-chloropyrimidin-4-yl) - N-methyl-2,3-methyl-2H-indazole-6-amine
Pazopanib Impurity 34
Pazopanil impurity 14
444731-75-3
44731-75-3